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基于序列的甲硝唑耐药艰难梭菌分离株的鉴定。

Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates.

出版信息

Emerg Infect Dis. 2022 Nov;28(11):2308-2311. doi: 10.3201/eid2811.220615.

DOI:10.3201/eid2811.220615
PMID:36286226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9622256/
Abstract

The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.

摘要

质粒 pCD-METRO 赋予艰难梭菌对甲硝唑的抗性。我们发现来自不同分离株的 pCD-METRO 质粒之间具有高度的序列相似性，并在美洲的临床和兽医储库中发现了 pCD-METRO 和相关的甲硝唑抗性分离株。我们建议使用 PCR 或基因组检测方法来检测甲硝唑抗性艰难梭菌中的 pCD-METRO。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd13/9622256/665b653c2592/22-0615-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd13/9622256/665b653c2592/22-0615-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd13/9622256/665b653c2592/22-0615-F.jpg

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2
Exploring bacterial diversity via a curated and searchable snapshot of archived DNA sequences.通过对存档DNA序列的精心整理和可搜索快照探索细菌多样性。
PLoS Biol. 2021 Nov 9;19(11):e3001421. doi: 10.1371/journal.pbio.3001421. eCollection 2021 Nov.
3
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4
Approaching pathogenic from a One Health perspective.从“同一个健康”视角看待致病性。
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PLoS One. 2021 May 12;16(5):e0245949. doi: 10.1371/journal.pone.0245949. eCollection 2021.
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