Division of Food and Nutrition, Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea.
Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.
Mar Drugs. 2022 Sep 27;20(10):609. doi: 10.3390/md20100609.
The present study aimed to investigate the antihypercholesterolemic effects of krill oil supplementation in high-cholesterol diet-induced hypercholesterolemic rats, and the mechanisms underlying these effects. Rats were divided into five groups: normal control, control (high-cholesterol diet), krill oil 100 mg/kg b.w. (high-cholesterol diet with Krill oil 100 mg/kg b.w.), and krill oil 200 mg/kg b.w. (high-cholesterol diet with Krill oil 200 mg/kg b.w.). After 12 weeks, the rats were sacrificed to observe the effects of krill oil on cholesterol synthesis and excretion. We found that krill oil supplementation suppressed total triglycerides, total cholesterol, and LDL-cholesterol levels, as well as HMG-CoA reductase activity. It stimulated AMPK phosphorylation, LDL receptor and ACAT2 expression in the liver, and the fecal output of cholesterol. Furthermore, it decreased the levels of P-selectin, sVCAM-1, and NO, as well as aortic wall thickness, demonstrating its role in the prevention of atherosclerosis. Thus, we suggest that krill oil supplementation can reduce LDL-cholesterol levels in the blood during hypercholesterolemia by stimulating the uptake of LDL-cholesterol into tissue and cholesterol excretion, as well as inhibition of cholesterol synthesis.
本研究旨在探讨磷虾油对高胆固醇饮食诱导的高脂血症大鼠的降胆固醇作用及其作用机制。将大鼠分为五组：正常对照组、对照组（高胆固醇饮食）、磷虾油 100mg/kg bw（高胆固醇饮食加磷虾油 100mg/kg bw）和磷虾油 200mg/kg bw（高胆固醇饮食加磷虾油 200mg/kg bw）。12 周后，处死大鼠观察磷虾油对胆固醇合成和排泄的影响。结果发现，磷虾油补充可抑制总甘油三酯、总胆固醇和 LDL-胆固醇水平以及 HMG-CoA 还原酶活性。它还刺激了肝脏中 AMPK 的磷酸化、LDL 受体和 ACAT2 的表达以及胆固醇的粪便排泄。此外，它还降低了 P-选择素、sVCAM-1 和 NO 的水平以及主动脉壁厚度，表明其在预防动脉粥样硬化方面的作用。因此，我们认为磷虾油补充可通过刺激 LDL-胆固醇进入组织和胆固醇排泄以及抑制胆固醇合成来降低高脂血症时血液中的 LDL-胆固醇水平。
