小菌落，大问题？新证据表明金黄色葡萄球菌小菌落变异体可加重囊性纤维化大鼠肺部炎症
Small Colonies, Bigger Problems? New Evidence That Staphylococcus aureus Small Colony Variants Can Worsen Lung Inflammation in Cystic Fibrosis Rats.
机构信息
Division of Pediatric Pulmonology, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
出版信息
Infect Immun. 2022 Nov 17;90(11):e0041322. doi: 10.1128/iai.00413-22. Epub 2022 Oct 26.
Abstract
Staphylococcus aureus is the most prevalent cystic fibrosis (CF) pathogen. During chronic airway infections, S. aureus adaptation to antibiotics includes evolving small colony variants (SCVs). Observational studies correlate SCVs with deteriorating lung function in CF, but it is unclear whether SCVs disease progression or if they are markers of intensified treatment. G. E. Bollar, J. D. Keith, A. M. Oden, M. R. Kiedrowski, and S. E. Birket (Infect Immun 90:e00237-22, 2022, https://doi.org/10.1128/iai.00237-22) provide intriguing new experimental evidence that an SCV elicits greater inflammation than its normal colony progenitor strain in CF rats.
摘要
金黄色葡萄球菌是最常见的囊性纤维化 (CF) 病原体。在慢性气道感染中，金黄色葡萄球菌对抗生素的适应包括产生小菌落变种 (SCV)。观察性研究将 SCV 与 CF 中肺功能恶化相关联，但尚不清楚 SCV 是导致疾病进展的原因，还是强化治疗的标志物。G. E. 博勒尔、J. D. 基思、A. M. 奥登、M. R. 基德罗夫斯基和 S. E. 伯克特（Infect Immun 90:e00237-22, 2022, https://doi.org/10.1128/iai.00237-22）提供了有趣的新实验证据，表明 CF 大鼠中的 SCV 比其正常菌落原代菌株引发更强烈的炎症。
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