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小菌落，大问题？新证据表明金黄色葡萄球菌小菌落变异体可加重囊性纤维化大鼠肺部炎症

Small Colonies, Bigger Problems? New Evidence That Staphylococcus aureus Small Colony Variants Can Worsen Lung Inflammation in Cystic Fibrosis Rats.

机构信息

Division of Pediatric Pulmonology, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

出版信息

Infect Immun. 2022 Nov 17;90(11):e0041322. doi: 10.1128/iai.00413-22. Epub 2022 Oct 26.

DOI:10.1128/iai.00413-22
PMID:36286497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9670989/
Abstract

Staphylococcus aureus is the most prevalent cystic fibrosis (CF) pathogen. During chronic airway infections, S. aureus adaptation to antibiotics includes evolving small colony variants (SCVs). Observational studies correlate SCVs with deteriorating lung function in CF, but it is unclear whether SCVs disease progression or if they are markers of intensified treatment. G. E. Bollar, J. D. Keith, A. M. Oden, M. R. Kiedrowski, and S. E. Birket (Infect Immun 90:e00237-22, 2022, https://doi.org/10.1128/iai.00237-22) provide intriguing new experimental evidence that an SCV elicits greater inflammation than its normal colony progenitor strain in CF rats.

摘要

金黄色葡萄球菌是最常见的囊性纤维化 (CF) 病原体。在慢性气道感染中，金黄色葡萄球菌对抗生素的适应包括产生小菌落变种 (SCV)。观察性研究将 SCV 与 CF 中肺功能恶化相关联，但尚不清楚 SCV 是导致疾病进展的原因，还是强化治疗的标志物。G. E. 博勒尔、J. D. 基思、A. M. 奥登、M. R. 基德罗夫斯基和 S. E. 伯克特（Infect Immun 90:e00237-22, 2022, https://doi.org/10.1128/iai.00237-22）提供了有趣的新实验证据，表明 CF 大鼠中的 SCV 比其正常菌落原代菌株引发更强烈的炎症。

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本文引用的文献

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Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung.金黄色葡萄球菌妥布霉素诱导的小菌落变异株急性感染导致囊性纤维化大鼠肺部炎症增加。
Infect Immun. 2022 Nov 17;90(11):e0023722. doi: 10.1128/iai.00237-22. Epub 2022 Sep 27.
2
Worldwide rates of diagnosis and effective treatment for cystic fibrosis.全球囊性纤维化的诊断和有效治疗率。
J Cyst Fibros. 2022 May;21(3):456-462. doi: 10.1016/j.jcf.2022.01.009. Epub 2022 Feb 4.
3
MRSA strains with distinct accessory genes predominate at different ages in cystic fibrosis.具有不同辅助基因的耐甲氧西林金黄色葡萄球菌菌株在囊性纤维化患者的不同年龄段占主导地位。
Pediatr Pulmonol. 2021 Sep;56(9):2868-2878. doi: 10.1002/ppul.25559. Epub 2021 Jul 16.
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Polyclonality, Shared Strains, and Convergent Evolution in Chronic Cystic Fibrosis Airway Infection.慢性囊性纤维化气道感染中的多克隆性、共享菌株与趋同进化
Am J Respir Crit Care Med. 2021 May 1;203(9):1127-1137. doi: 10.1164/rccm.202003-0735OC.
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Sustained Coinfections with and in Cystic Fibrosis.囊性纤维化中 与 的持续共感染。
Am J Respir Crit Care Med. 2021 Feb 1;203(3):328-338. doi: 10.1164/rccm.202004-1322OC.
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Prevalence and clinical associations of Staphylococcus aureus small-colony variant respiratory infection in children with cystic fibrosis (SCVSA): a multicentre, observational study.儿童囊性纤维化中小菌落变异金黄色葡萄球菌呼吸道感染的流行情况及其临床相关性（SCVSA）：一项多中心观察性研究。
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