产 KPC-31 碳青霉烯酶，一种与头孢他啶-阿维巴坦耐药相关的 KPC-3 变体，在广泛耐药的 ST235 铜绿假单胞菌临床分离株中出现。
Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate.
机构信息
Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI) - ANLIS "Dr. Carlos G. Malbrán", Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
出版信息
Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0064822. doi: 10.1128/aac.00648-22. Epub 2022 Oct 26.
Abstract
A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the Ω loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer.
摘要
阿根廷从一名气管抽吸患者的标本中分离出一株产头孢他啶-阿维巴坦耐药 KPC 的铜绿假单胞菌。该患者接受头孢他啶-阿维巴坦联合其他药物治疗 130 天。对铜绿假单胞菌的全基因组测序发现 KPC-3 的Ω环中的 D179Y 取代，对应于整合在染色体上的 KPC-31。该菌株属于序列型 235/O11（ST235/O11）高危克隆。对临床实验室最常使用的碳青霉烯酶检测方法进行评估未能鉴定该分离株为 KPC 产生菌。
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