[氨基芳基噻唑的辐射防护活性及多种作用机制]
[Radioprotective activity of aminoarylthiazoles and various mechanisms of action].
作者信息
Vladimirov V G, Chupakhin O N, Novikova A P, Egorova L G, Libikova N I
出版信息
Radiobiologiia. 1987 Jul-Aug;27(4):528-32.
PMID:3628735
Abstract
The amino group is shown to be the reaction center that is primarily responsible for the radioprotective effect of the thiazoles under study. A phenyl residue also contributes to the radioprotective effect. The influence of thiazoles on DNA biosynthesis on radiosensitive tissues plays an important role in the biochemical mechanism of their radioprotective action.
摘要
氨基被证明是反应中心，它主要负责所研究的噻唑类化合物的辐射防护作用。苯基残基也对辐射防护作用有贡献。噻唑类化合物对放射敏感组织中DNA生物合成的影响在其辐射防护作用的生化机制中起重要作用。
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