[二甲基氨基二噻嗪的抗辐射活性及作用机制]
[The antiradiation activity and mechanism of action of dimethylaminodithiazines].
作者信息
Vladimirov V G, Strel'nikov Iu E, Amosova S V, Gavrilova G M, Gostevskaia V I, Petrov A S, Sharova L A
出版信息
Radiobiologiia. 1990 Jan-Feb;30(1):69-75.
PMID:2107560
Abstract
A new group of radioprotective agents, dimethylaminodithiazines, was discovered. The agents are effective when used in relatively small amounts and exert a radioprotective effect rapidly with both intraperitoneal and per os injections. The role of inhibition of oxidative processes and DNA biosynthesis in the mechanism of radioprotective action of dimethylaminodithiazines is discussed.
摘要
发现了一类新的辐射防护剂——二甲基氨基二噻嗪。这些药剂在使用相对少量时就有效，并且通过腹腔注射和口服给药都能迅速发挥辐射防护作用。讨论了抑制氧化过程和DNA生物合成在二甲基氨基二噻嗪辐射防护作用机制中的作用。
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