Sardar A, Juorio A V
Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(2-3):309-13. doi: 10.1016/0278-5846(87)90075-3.
These experiments show that in the rat corpus striatum the highest concentrations of p- and m-tyramine were found in the caudate nucleus while somewhat lower values were observed in the putamen and globus pallidus. Inhibition of monoamine oxidase by pargyline produced an increase in the concentration of both tyramines in the three areas. The effect of pargyline is more marked with p-tyramine, however, the regional distribution of both p- and m-tyramine are preserved after monoamine oxidase inhibition. In addition, the pargyline treatment produced a significant reduction in corpus striatum p-tyrosine while no changes were observed in the tryptophan concentrations.
这些实验表明，在大鼠纹状体中，尾状核中对酪氨酸和间酪氨酸的浓度最高，而壳核和苍白球中的浓度略低。帕吉林对单胺氧化酶的抑制作用使这三个区域中两种酪氨酸的浓度均升高。然而，帕吉林对p - 酪氨酸的作用更为显著，单胺氧化酶抑制后，p - 酪氨酸和间酪氨酸的区域分布仍得以保留。此外，帕吉林处理使纹状体p - 酪氨酸显著降低，而色氨酸浓度未观察到变化。
