Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Neuroepidemiology. 2023;57(1):51-64. doi: 10.1159/000527372. Epub 2022 Oct 26.
China has the most people with Parkinson disease (PD) in the world and is estimated to have over half of the worldwide PD population. The objective of this study was to analyze the corresponding burden of PD in China for the past decades.
Data on disease burden related to PD in China were retrieved from the Global Burden of Disease (GBD) 2019 study. The estimated annual percentage changes (EAPCs) were calculated to assess temporal trends, and the ratio of years lived with disability (YLDs) to disability-adjusted life years (DALYs) was used as an index to evaluate the healthcare system.
Nationally, the burden of PD increased from 1990 to 2019. Although the age-standardized incidence rate (ASIR) increased, the age-standardized death rate (ASDR) and age-standardized DALY rate both decreased. Age-standardized rates of PD in males remained higher than those in females, but trends in ASDR and the age-standardized DALY rate for females showed a pronounced decrease. The most remarkable increase in the ASIR was in individuals aged 45-49 years, with an EAPC of 1.74 (95% confidence interval, 1.26-2.21). The YLDs:DALYs ratio continuously increased compared with global figures and even with countries with high sociodemographic index (SDI).
Although ASDR and age-standardized DALY rates for PD have been declining, the burden of PD still needs attention as the total numbers have increased over the period. Generally, the greater burden of PD was in males. A sound health system with services tailored to PD continues to be required in the future.
中国是世界上帕金森病（PD）患者最多的国家，据估计，全球 PD 患者中有一半以上在中国。本研究旨在分析过去几十年中国 PD 的相应负担。
从全球疾病负担（GBD）2019 研究中检索了中国 PD 相关疾病负担的数据。计算了估计的年变化百分比（EAPC）以评估时间趋势，并使用残疾调整生命年（DALY）中残疾生命年（YLD）的比例作为评估医疗保健系统的指标。
从 1990 年到 2019 年，全国 PD 负担增加。尽管年龄标准化发病率（ASIR）增加，但年龄标准化死亡率（ASDR）和年龄标准化 DALY 率均下降。男性的年龄标准化 PD 率仍然高于女性，但女性的 ASDR 和年龄标准化 DALY 率趋势呈明显下降。ASIR 增幅最大的是 45-49 岁的人群，EAPC 为 1.74（95%置信区间，1.26-2.21）。与全球数据相比，YLDs:DALYs 比值连续增加，甚至与高社会人口指数（SDI）国家相比也是如此。
尽管 PD 的 ASDR 和年龄标准化 DALY 率一直在下降，但由于该时期的总人数增加，PD 的负担仍需要引起关注。一般来说，PD 的负担更大的是男性。未来仍需要有针对性的服务的健全卫生系统。
