Brynes R K, McKenna R W, Sundberg R D
Am J Clin Pathol. 1978 Nov;70(5):753-9. doi: 10.1093/ajcp/70.5.753.
Recent advances in the treatment of hematologic malignancies have been paralleled by renewed interest on the part of pathologists and hematologists in methods of obtaining and preparing bone marrow for diagnostic studies. A thorough bone marrow morphologic study involves examination of peripheral blood smears, direct, particle, and buffy coat bone marrow smears, trephine biopsy imprints, particle and trephine biopsy sections, and marrow volumetric data. The information obtained from the study of these various specimens is complementary. Frequently it is a combination of clues gathered from examination of several different preparations that leads to a correct diagnosis. Utilization of biopsy material by the methods described provides complete, accurate and reproducible information and minimizes the necessity for repeating a biopsy for morphologic diagnosis or ancillary studies.
血液系统恶性肿瘤治疗方面的最新进展，同时也引发了病理学家和血液学家对获取和制备用于诊断研究的骨髓方法的新兴趣。全面的骨髓形态学研究包括对外周血涂片、直接涂片、颗粒涂片和血沉棕黄层骨髓涂片、环钻活检印片、颗粒和环钻活检切片以及骨髓容积数据的检查。从对这些不同标本的研究中获得的信息是互补的。通常，从对几种不同制剂的检查中收集到的线索组合起来才能得出正确的诊断。通过所述方法利用活检材料可提供完整、准确且可重复的信息，并将为进行形态学诊断或辅助研究而重复活检的必要性降至最低。
