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中度高血糖可抑制黑色素瘤向肝脏转移。

Moderate hyperglycemia suppresses melanoma metastasis to liver.

机构信息

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.

Department of Industrial Technology and Innovation, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.

出版信息

Exp Anim. 2023 May 17;72(2):183-192. doi: 10.1538/expanim.22-0078. Epub 2022 Oct 27.

DOI:10.1538/expanim.22-0078
PMID:36288978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10202721/
Abstract

The metastasis of various cancers is promoted by hyperglycemia. In contrast, melanoma and colorectal cancer seemed to be exceptional. We confirmed that the metastasis of melanoma B16-F10 could be suppressed by hyperglycemia. It was attractive from the prognostic point of view of the prevention of metastasis, though the problem of the risk of diabetes remained. Then, the effect of moderate hyperglycemic condition was investigated using a pre-diabetic model mouse (GKKO mouse). The metastasis of B16-F10 cells to liver was focused and the number and volume of metastatic colonies in liver were analyzed. The medians of the number of metastatic colonies in GKKO mice were 0.57-fold (P=0.06) compared to control mice. Analysis of macrophage markers revealed upregulation of CD86, a tumor-suppressive M1-type marker, and downregulation of CD206, a tumor-promotive M2-type marker. A tendency of upregulation of Cxcl10, a pro-inflammatory cytokine was also observed. Regarding cellular activities of B16-F10, migration activity and invasion activity were reduced by moderate hyperglycemia. In conclusion, metastasis of B16-F10 cells to liver could be suppressed by moderate hyperglycemia without the risk of diabetes. This information should contribute to dietary planning during prognosis.

摘要

高血糖促进各种癌症的转移。相比之下，黑色素瘤和结直肠癌似乎是例外。我们证实，高血糖可抑制黑色素瘤 B16-F10 的转移。从预防转移的预后角度来看，这很有吸引力，尽管仍存在糖尿病风险的问题。然后，使用糖尿病前期模型小鼠（GKKO 小鼠）研究了中度高血糖状态的影响。重点关注 B16-F10 细胞向肝脏的转移，并分析肝脏中转移性集落的数量和体积。GKKO 小鼠中转移性集落的中位数比对照小鼠低 0.57 倍（P=0.06）。对巨噬细胞标志物的分析显示，肿瘤抑制型 M1 标志物 CD86 的上调和肿瘤促进型 M2 标志物 CD206 的下调。促炎细胞因子 Cxcl10 的上调也呈趋势。关于 B16-F10 的细胞活性，中度高血糖可降低其迁移和侵袭活性。总之，中度高血糖可抑制 B16-F10 细胞向肝脏的转移，且无糖尿病风险。这些信息应该有助于预后期间的饮食计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/e12ddbbc3798/expanim-72-183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/032b7a56dd5a/expanim-72-183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/9f5ced342750/expanim-72-183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/50ddb8d8bf83/expanim-72-183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/e12ddbbc3798/expanim-72-183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/032b7a56dd5a/expanim-72-183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/9f5ced342750/expanim-72-183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/50ddb8d8bf83/expanim-72-183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1357/10202721/e12ddbbc3798/expanim-72-183-g004.jpg

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Med Sci Monit. 2021 Aug 19;27:e930921. doi: 10.12659/MSM.930921.
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Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6.Nanog 过表达对小鼠黑色素瘤细胞系 B16-BL6 转移潜能的影响。
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