Department of Neurology, Musashino Red Cross Hospital, Japan.
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan.
Intern Med. 2023 Jun 1;62(11):1653-1657. doi: 10.2169/internalmedicine.9783-22. Epub 2022 Oct 26.
Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.
视神经脊髓炎谱系疾病以前曾在副肿瘤情况下报道过，尽管其发病机制尚无明确共识。本文报告了一例结肠癌相关的水通道蛋白 4 抗体阳性的视神经脊髓炎谱系疾病。患者为 64 岁女性，行肿瘤切除术，随后血清水通道蛋白 4 抗体滴度转为阴性。血清样本还对葡萄糖调节蛋白 78 抗体呈阳性，最近有研究提示该抗体是破坏血脑屏障的新因素。本病例的血清学和病理学研究强调了水通道蛋白 4 和葡萄糖调节蛋白 78 抗体在副肿瘤情况下的作用和参与。
