Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan.
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.
JAMA Neurol. 2014 Apr;71(4):495-8. doi: 10.1001/jamaneurol.2013.6331.
Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis.
In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department at Wayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation.
This case extends the context of NMOSD as a paraneoplastic disorder.
肿瘤患者中出现视神经脊髓炎谱系疾病（NMOSD）的报道表明，水通道蛋白-4 自身免疫在某些情况下可能具有副肿瘤基础。
在本病例报告中，我们描述了一位 NMOSD 患者，其检测结果为水通道蛋白-4 IgG 阳性，且患有小肠神经内分泌肿瘤的肝转移。肿瘤细胞表达水通道蛋白-4 免疫反应性。她因双侧下肢无力、上升性感觉异常和感觉减退到韦恩州立大学神经科就诊。
本病例扩展了 NMOSD 作为副肿瘤疾病的范畴。
