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饥饿腺瘤中羟乙基淀粉引起的容积变化及其作用机制。

Hetastarch induced volume changes of starving adenoma and suggested mechanism of action.

机构信息

Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Prague, Czech Republic.

Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovakia.

出版信息

Sci Rep. 2022 Oct 26;12(1):17988. doi: 10.1038/s41598-022-21693-4.

DOI:10.1038/s41598-022-21693-4
PMID:36289259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9606266/
Abstract

Submucosal injection is often required step during endoscopic mucosal resection (EMR). In clinical practice we have observed that the EMR injection solution containing hetastarch (HES) lead to selective increase of the neoplasms volume, facilitating their resection. The aim of this study was to explore the possible mechanisms of such behaviour, which was not reported elsewhere. The HCT116 cell line of human colon cancer was exposed to the same EMR solution in vitro. The significant volume increase of HCT116 cells was observed, but only for starving cell culture, suggesting that the starving is essential for the neoplasms-specific volume change. We suggest, that for the iso-oncotic composition of the EMR submucosa injection solution the HES component is crucial, as it can be subject of the starch hydrolysis followed by facilitated transport of resulting monosaccharides from the submucosa into the neoplastic tissue.

摘要

黏膜下注射通常是内镜下黏膜切除术（EMR）过程中的必要步骤。在临床实践中，我们观察到含有羟乙基淀粉（HES）的 EMR 注射溶液会导致肿瘤体积选择性增加，从而更便于切除。本研究旨在探索这种行为的可能机制，这在其他地方尚未报道过。体外将人结肠癌细胞系 HCT116 暴露于相同的 EMR 溶液中。观察到 HCT116 细胞的显著体积增加，但仅在饥饿细胞培养中观察到，这表明饥饿对于肿瘤特异性体积变化是必要的。我们推测，对于 EMR 黏膜下注射溶液的等渗组成，HES 成分是至关重要的，因为它可能会经历淀粉水解，随后促进从黏膜下层进入肿瘤组织的单糖的易位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/b224f62dadb4/41598_2022_21693_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/6b39fda0de9d/41598_2022_21693_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/bfeb4b2e5f85/41598_2022_21693_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/9581acd26364/41598_2022_21693_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/cb2adce0b59e/41598_2022_21693_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/6293529f25a9/41598_2022_21693_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/b224f62dadb4/41598_2022_21693_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/6b39fda0de9d/41598_2022_21693_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/bfeb4b2e5f85/41598_2022_21693_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/9581acd26364/41598_2022_21693_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/cb2adce0b59e/41598_2022_21693_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/6293529f25a9/41598_2022_21693_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0260/9606266/b224f62dadb4/41598_2022_21693_Fig6_HTML.jpg

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