Borges-Canha Marta, Neves João Sérgio, Silva Maria Manuel, Mendonça Fernando, Moreno Telma, Ribeiro Sara, Correa João, Vale Catarina, Gonçalves Juliana, Urbano Ferreira Helena, Gil-Santos Sara, Guerreiro Vanessa, Sande Ana, B Souto Selma, Pedro Jorge, Freitas Paula, Carvalho Davide
Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar Universitário de São João, 4200-319 Porto, Portugal.
Departamento de Cirurgia e Fisiologia, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.
Biomedicines. 2022 Sep 27;10(10):2416. doi: 10.3390/biomedicines10102416.
Non-alcoholic fatty liver disease (NAFLD) is associated with several other metabolic disorders, which are typically pro-inflammatory states. Body fat content is an important marker of metabolic health and abdominal fat is associated with harmful cardiometabolic outcomes. We aimed to evaluate the association between the risk of NAFLD (through Fatty Liver Index (FLI), and BMI, AST/ALT ratio, and presence of diabetes (BARD)), and anthropometric parameters, predictors of metabolic status, in patients with morbid obesity, and to evaluate the association of FLI and BARD scores with pro-inflammatory markers. We have retrospectively studied patients with morbid obesity followed in our center. In total, 2184 participants were included, with an average age of 42.8 ± 10.6 years, 84.5% being females. We report a positive association of FLI with waist circumference (β = 0.10 [0.09 to 0.11], p < 0.01) and waist-to-hip ratio (β = 8.68 [6.85 to 10.52, p < 0.01]), even after adjusting for age, sex, body mass index, diabetes, and dyslipidemia (p < 0.01 for both adjusted models). The associations of BARD with anthropometric measures were significant only in the non-adjusted model. There was a positive association between both FLI and BARD and C-reactive protein. Our results point towards a positive association between waist-to-hip ratio and the risk of hepatic steatosis, and between pro-inflammatory markers and both hepatic steatosis and fibrosis.
非酒精性脂肪性肝病（NAFLD）与其他几种代谢紊乱相关，这些代谢紊乱通常处于促炎状态。体脂含量是代谢健康的重要指标，腹部脂肪与有害的心脏代谢结局相关。我们旨在评估病态肥胖患者中NAFLD风险（通过脂肪肝指数（FLI）、体重指数、AST/ALT比值和糖尿病的存在情况（BARD））与人体测量参数（代谢状态的预测指标）之间的关联，并评估FLI和BARD评分与促炎标志物之间的关联。我们对在我们中心随访的病态肥胖患者进行了回顾性研究。总共纳入了2184名参与者，平均年龄为42.8±10.6岁，其中84.5%为女性。我们报告，即使在调整年龄、性别、体重指数、糖尿病和血脂异常后，FLI与腰围（β = 0.10 [0.09至0.11]，p < 0.01）和腰臀比（β = 8.68 [6.85至10.52]，p < 0.01）仍呈正相关（两个调整模型的p均< 0.01）。BARD与人体测量指标的关联仅在未调整模型中显著。FLI和BARD与C反应蛋白之间均呈正相关。我们的结果表明腰臀比与肝脂肪变性风险之间、促炎标志物与肝脂肪变性和纤维化之间均呈正相关。
