Urso Daniele, Zoccolella Stefano, Gnoni Valentina, Logroscino Giancarlo
Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy.
Department of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
Biomedicines. 2022 Oct 11;10(10):2537. doi: 10.3390/biomedicines10102537.
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing evidence that the neurodegeneration during the course of the disease can also involve other motor and non-motor regions. In this review, we analyzed and discussed available data from epidemiological population-based studies on extrapyramidal and non-motor features during the course of ALS.
肌萎缩侧索硬化症（ALS）是最常见的运动神经元疾病（MND），在西方国家的各种疾病中，其发病率增长幅度最大。尽管ALS的典型临床表型涉及上下运动神经元同时受累，但越来越多的证据表明，疾病过程中的神经退行性变也可能累及其他运动和非运动区域。在本综述中，我们分析并讨论了基于人群的流行病学研究中有关ALS病程中锥体外系和非运动特征的现有数据。
