Owiny J R, Fitzpatrick R J, Spiller D G, Appleton J
Res Vet Sci. 1987 Jul;43(1):36-43.
There was a progressive loosening of the collagenous fibre bundles in the stroma of the ovine cervix during spontaneous parturition. The change from an organ with predominantly thick collagen fibre bundles to one with a loose network of collagen fibrils was associated in time with a threefold increase in softness as measured by the Stretch modulus. Infusion of oestradiol 17 beta (E2 beta) for 18 hours elicited similar changes in the structure and mechanical properties of the cervix. Infusion of sodium meclofenamate for 18 hours significantly (P less than 0.005) reduced the effect of E2 beta administered simultaneously.
在绵羊自然分娩过程中，其子宫颈基质中的胶原纤维束逐渐松弛。从一个主要由粗大胶原纤维束构成的器官转变为一个具有疏松胶原原纤维网络的器官，与此同时，通过拉伸模量测量发现其柔软度增加了两倍。注射17β-雌二醇（E2β）18小时会引起子宫颈结构和力学性能的类似变化。注射甲氯芬那酸钠18小时可显著（P<0.005）降低同时注射的E2β的作用。
