Pipano E, Markovics A, Kriegel Y, Frank M, Fish L
Res Vet Sci. 1987 Jul;43(1):64-6.
Forty Friesian one-year-old calves were vaccinated simultaneously with live Babesia bovis and B bigemina vaccines. Three groups of 10 calves each were treated with two, three or four doses of 20 mg kg-1 long-acting oxytetracycline (OTC/LA) at six- to seven-day intervals starting from day 6 after vaccination. Ten animals remained untreated. The treated calves showed considerably fewer days of patency and higher packed cell volumes than the vaccinated untreated calves. All calves developed serum antibodies to both parasites following vaccination. Five months later the 40 vaccinated and 30 new calves were challenged with syringe-transferred virulent parasites of both species. The vaccinated calves showed no parasites or clinical manifestations while calves of the new group exhibited severe clinical babesiosis. These results show that when OTC/LA is administered following anti-babesial vaccination, parasitaemia and red blood cell destruction are significantly reduced without, however, inhibiting the development of immunity.
四十头一岁的弗里斯兰小牛同时接种了活的牛巴贝斯虫疫苗和双芽巴贝斯虫疫苗。从接种疫苗后的第6天开始，每组10头小牛，共三组，分别每隔6至7天接受两剂、三剂或四剂20毫克/千克的长效土霉素（OTC/LA）治疗。十头动物未接受治疗。与未接受治疗的接种小牛相比，接受治疗的小牛的排虫天数明显减少，红细胞压积更高。所有小牛在接种疫苗后均产生了针对两种寄生虫的血清抗体。五个月后，对40头接种过疫苗的小牛和30头新小牛用注射器接种两种物种的强毒寄生虫进行攻毒。接种过疫苗的小牛未出现寄生虫或临床表现，而新组的小牛则表现出严重的临床巴贝斯虫病。这些结果表明，在抗巴贝斯虫疫苗接种后给予OTC/LA时，寄生虫血症和红细胞破坏会显著减少，然而，并不会抑制免疫力的发展。
