Andrade Mariana, Oliveira Ketlyn, Morais Catarina, Abrantes Patrícia, Pomba Constança, Rosato Adriana E, Couto Isabel, Costa Sofia Santos
Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal.
Centre of Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.
Antibiotics (Basel). 2022 Sep 30;11(10):1339. doi: 10.3390/antibiotics11101339.
Coagulase-positive staphylococci (CoPS) account for most bacteria-related pyoderma in companion animals. Emergence of methicillin-resistant strains of (MRSP), (MRSA) or (MRSC), often with multidrug-resistant (MDR) phenotypes, is a public health concern. The study collection comprised 237 staphylococci ( ( = 155), ( = 55) and ( = 27)) collected from companion animals, previously characterized regarding resistance patterns and clonal lineages. Biofilm production was detected for 51.0% (79/155), 94.6% (52/55) and 88.9% (24/27) of the , and respectively, and was a frequent trait of the predominant and clonal lineages. The production of biofilm varied with NaCl supplementation of the growth media. All and strains carried . Kaplan-Meier survival analysis of infected with different CoPS revealed a higher virulence potential of when compared with other CoPS. Our study highlights a high frequency of biofilm production by prevalent antimicrobial-resistant clonal lineages of CoPS associated with animal pyoderma, potentially related with a higher virulence potential and persistent or recurrent infections.
凝固酶阳性葡萄球菌（CoPS）是伴侣动物中大多数细菌性脓皮病的病因。耐甲氧西林葡萄球菌（MRSP）、耐甲氧西林金黄色葡萄球菌（MRSA）或耐甲氧西林表皮葡萄球菌（MRSC）的出现，通常伴有多重耐药（MDR）表型，这是一个公共卫生问题。该研究收集了237株葡萄球菌（金黄色葡萄球菌（n = 155）、表皮葡萄球菌（n = 55）和腐生葡萄球菌（n = 27）），这些菌株来自伴侣动物，之前已对其耐药模式和克隆谱系进行了鉴定。检测发现，金黄色葡萄球菌、表皮葡萄球菌和腐生葡萄球菌中分别有51.0%（79/155）、94.6%（52/55）和88.9%（24/27）产生生物膜，这是主要的金黄色葡萄球菌和表皮葡萄球菌克隆谱系的常见特征。生物膜的产生随生长培养基中氯化钠的添加而变化。所有金黄色葡萄球菌和表皮葡萄球菌菌株都携带[相关基因或因子，原文未明确写出]。对感染不同CoPS的[宿主，原文未明确写出]进行Kaplan-Meier生存分析发现，与其他CoPS相比，金黄色葡萄球菌的毒力潜力更高。我们的研究强调，与动物脓皮病相关的CoPS常见抗菌耐药克隆谱系产生生物膜的频率很高，这可能与更高的毒力潜力以及持续性或复发性感染有关。
