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肝脏代谢组学和转录组学的综合分析揭示了宫内生长受限仔猪的氧化应激。

Integrative Analysis of Liver Metabolomics and Transcriptomics Reveals Oxidative Stress in Piglets with Intrauterine Growth Restriction.

作者信息

Gao Hongmei, Chen Xiaoyou, Zhao Junxing, Xue Zhenhua, Zhang Longchao, Zhao Fuping, Wang Bingyuan, Wang Lixian

机构信息

Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

College of Animal Sciences, Shanxi Agricultural University, Jinzhong 030801, China.

出版信息

Biology (Basel). 2022 Sep 29;11(10):1430. doi: 10.3390/biology11101430.

DOI:10.3390/biology11101430
PMID:36290334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9598470/
Abstract

The correlation between oxidative stress and liver metabolic dysfunction in piglets with intrauterine growth restriction (IUGR) remains limited. Therefore, the objective of the present study was to investigate potential mechanisms of metabolic characteristics induced by oxidative stress in the livers of IUGR piglets using metabolomic and transcriptomic analysis. Analysis of the phenotypic characteristics showed that the liver weight of the intrauterine growth restriction piglets was significantly lower than that of normal birth weight piglets. Intrauterine growth restriction piglets exhibited disordered hepatic cord arrangement and vacuolization as well as excessive lipid accumulation in hepatocytes. In addition, the activities of antioxidant enzymes were significantly decreased in the liver of the intrauterine growth restriction piglets, whereas the level of the lipid peroxidation marker MDA was significantly increased. Finally, our findings revealed that intrauterine growth restriction piglets were involved in a variety of metabolic abnormalities, including mitochondrial dysfunction, imbalance of fatty acid composition, disruption to sources of one-carbon unit supply, and abnormal galactose conversion, which may be responsible for oxidative stress in the liver. In summary, these data provided a detailed theoretical reference for revealing the hepatic metabolic characteristics of intrauterine growth restriction piglets.

摘要

宫内生长受限（IUGR）仔猪氧化应激与肝脏代谢功能障碍之间的相关性仍然有限。因此，本研究的目的是利用代谢组学和转录组学分析，探讨氧化应激诱导IUGR仔猪肝脏代谢特征的潜在机制。表型特征分析表明，宫内生长受限仔猪的肝脏重量显著低于正常出生体重仔猪。宫内生长受限仔猪表现出肝索排列紊乱、空泡化以及肝细胞内脂质过度积累。此外，宫内生长受限仔猪肝脏中抗氧化酶的活性显著降低，而脂质过氧化标志物丙二醛（MDA）的水平显著升高。最后，我们的研究结果表明，宫内生长受限仔猪存在多种代谢异常，包括线粒体功能障碍、脂肪酸组成失衡、一碳单位供应来源紊乱以及半乳糖转化异常，这些可能是肝脏氧化应激的原因。总之，这些数据为揭示宫内生长受限仔猪的肝脏代谢特征提供了详细的理论参考。

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