Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
Front Public Health. 2022 Jan 21;9:767545. doi: 10.3389/fpubh.2021.767545. eCollection 2021.
Early onset hypertension is one of many major medical disorders that have evolved over the current millennium across both the developing as well as the developed world. Though various mechanisms have been postulated for the evolution of hypertension in these individuals, one of the most relevant ones is that of low birth weight and its association with hypertension. Barker from historical evidence has postulated the foetal onset adult disease (FOAD) or Thrifty phenotype on Low Birth Weight (LBW) associated hypertension. Later, Brenner highlighted the importance of low nephron mass and future implications. In this review we elaborate the mechanisms that were postulated for LBW-related hypertension as well the potential antihypertensive therapy that may be used in these individuals.
早发性高血压是当前千年在发展中国家和发达国家都出现的众多主要医学疾病之一。尽管已经提出了多种机制来解释这些人患高血压的原因，但其中一个最相关的机制是低出生体重及其与高血压的关联。Barker 根据历史证据提出了胎儿起源的成人疾病（FOAD）或与低出生体重（LBW）相关的节俭表型假说。后来，Brenner 强调了低肾小球数量的重要性及其对未来的影响。在这篇综述中，我们详细阐述了 LBW 相关高血压的假设机制，以及可能用于这些人群的潜在降压治疗方法。
