Bandala Cindy, Cárdenas-Rodríguez Noemi, Reyes-Long Samuel, Cortes-Altamirano José Luis, Garciadiego-Cázares David, Lara-Padilla Eleazar, Ibáñez-Cervantes Gabriela, Mancilla-Ramírez Javier, Gómez-Manzo Saul, Alfaro-Rodríguez Alfonso
Neurociencias Básicas, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Mexico City 14389, Mexico.
Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Antioxidants (Basel). 2022 Oct 1;11(10):1972. doi: 10.3390/antiox11101972.
Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients.
Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation.
Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management.
Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.
肥胖仍然是一个全球性的健康问题。这种病理状态下的慢性低度炎症与认知改变等合并症有关，从长远来看，认知改变可能导致神经退行性疾病。肥胖和2型糖尿病患者的神经炎症或胶质细胞增生与脂肪因子、高血脂和高血糖的作用有关，这些因素会增加自由基的产生。脑胶质细胞增生可能是神经退行性疾病发展的一个危险因素，而抗氧化剂可能是预防和治疗肥胖患者神经合并症的一种选择。
确定肥胖患者产生胶质细胞增生的免疫和氧化应激机制，并提出抗氧化剂作为减轻神经炎症的一种选择。
在科学数据库进行高级检索：PubMed、ProQuest、EBSCO和科学引文索引，以查找肥胖患者胶质细胞增生的病理生理学研究以及抗氧化剂在其管理中的可能作用。
肥胖患者可能会发生神经炎症，这是由多种脂肪因子、脂质和葡萄糖过多引起的，这会导致自由基增加，必须用抗氧化剂来中和，以减少胶质细胞增生和长期神经退行性变的风险。
