Pizent Alica, Anđelković Milena, Tariba Lovaković Blanka, Živković Semren Tanja, Buha Djordjevic Aleksandra, Gamulin Marija, Bonderović Vera, Aćimović Miodrag, Bulat Zorica
Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.
Health Center Kosovska Mitrovica, 38220 Kosovska Mitrovica, Serbia.
Antioxidants (Basel). 2022 Oct 18;11(10):2044. doi: 10.3390/antiox11102044.
We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.
我们研究了接触各种金属（类金属）（砷、镉、铬、汞、镍和铅）在前列腺癌中的潜在作用。建立了两个队列：克罗地亚队列，由62例病例和30例对照组成；塞尔维亚队列，由41例病例和61例对照组成。采集了血液/血清样本。测定了所采集样本中所研究金属（类金属）的水平、氧化应激的各种参数以及前列腺特异性抗原（PSA）。对来自克罗地亚和塞尔维亚队列的103名前列腺癌患者和91名对照男性的测量参数进行比较，结果显示前列腺癌患者血液中的汞、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）水平显著高于对照组，而血清巯基（SH）水平显著低于对照组。相关性分析揭示了氧化应激的某些参数与所测金属（类金属）浓度之间的显著关系，表明金属（类金属）诱导的氧化应激失衡可能发挥作用。此外，在前列腺癌患者中发现血液铅与血清PSA之间存在显著的负相关，但在对其余参数的影响进行模型调整后，未发现血清PSA与所测参数之间存在显著关联。总体研究结果表明，所测金属（类金属）对氧化/抗氧化系统失衡有重大影响。尽管结果有些相互矛盾，但本研究结果表明所研究的金属（类金属）在前列腺癌中可能发挥作用，尤其是汞，因为在两个队列中均观察到了所获得的关系，其次是氧化应激状态的紊乱，且发现其与汞水平相关。然而，有必要在更大的队列中进行进一步研究，以解释和证实所获得的结果。
