Lazzarin Taline, Garcia Leonardo Rufino, Martins Danilo, Queiroz Diego Aparecido Rios, Tonon Carolina Rodrigues, Balin Paola da Silva, Polegato Bertha Furlan, Paiva Sergio Alberto Rupp de, Azevedo Paula Schmidt, Minicucci Marcos, Zornoff Leonardo
Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.
Surgery and Orthopedics Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.
Antioxidants (Basel). 2022 Oct 20;11(10):2064. doi: 10.3390/antiox11102064.
Cardiac remodeling is defined as a group of molecular, cellular, and interstitial changes that manifest clinically as changes in the heart's size, mass, geometry, and function after different injuries. Importantly, remodeling is associated with increased risk of ventricular dysfunction and heart failure. Therefore, strategies to attenuate this process are critical. Reactive oxygen species and oxidative stress play critical roles in remodeling. Importantly, antioxidative dietary compounds potentially have protective properties against remodeling. Therefore, this review evaluates the role of nutrients and food as modulators of cardiac remodeling.
心脏重塑被定义为一组分子、细胞和间质变化，临床上表现为心脏在遭受不同损伤后其大小、质量、几何形状和功能的改变。重要的是，重塑与心室功能障碍和心力衰竭风险增加相关。因此，减轻这一过程的策略至关重要。活性氧和氧化应激在重塑过程中起关键作用。重要的是，具有抗氧化作用的膳食化合物可能具有预防重塑的特性。因此，本综述评估了营养素和食物作为心脏重塑调节因子的作用。
