Microelectronic Circuits Centre Ireland (MCCI), Tyndall National Institute, T12 R5CP Cork, Ireland.
Biophotonics@Tyndall, IPIC, Tyndall National Institute, T12 R5CP Cork, Ireland.
Biosensors (Basel). 2022 Sep 26;12(10):793. doi: 10.3390/bios12100793.
This work is an overview of silicon photomultipliers (SiPMs) with a view to defining their importance for bio-photonic and clinical applications. SiPMs are benchmarked against other common photodetectors, namely, PIN diodes and avalanche photodetectors (APDs) and are compared with respect to important circuit design parameters. It will be shown that careful selection of the design bias voltage, overvoltage, gain defining components and device integration to micro-optics can allow SiPM detectors to achieve considerable sensitivity for auto-fluorescence (AF) detection and a wide dynamic range at low optical powers (1 pW to ~4 μW). The SiPM has a manageable bias voltage (25 V to ~30 V DC) for systems integration, and with optimised sensitivity it will enhance bio-photonic research in the area of AF to detect intraoperatively, for example, brain tumour margins.
这项工作概述了硅光电倍增管（SiPM），旨在确定它们在生物光子学和临床应用中的重要性。SiPM 与其他常见的光电探测器（即 PIN 二极管和雪崩光电二极管（APD））进行了基准测试，并就重要的电路设计参数进行了比较。结果表明，仔细选择设计偏置电压、过电压、增益确定元件以及与微光学的器件集成，可以使 SiPM 探测器在低光功率（约 1 pW 至约 4 μW）下实现对自发荧光（AF）检测的相当高的灵敏度和宽动态范围。SiPM 的偏置电压（约 25 V 至约 30 V DC）便于系统集成，并且通过优化灵敏度，可以增强生物光子学在 AF 检测方面的研究，例如，用于术中检测脑瘤边缘。
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