Dubljević Olga, Ković Vanja, Pavković Željko, Mitić Miloš, Pešić Vesna
Department of Neurobiology, Institute for Biological Research ''Siniša Stanković''-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
Laboratory for Neurocognition and Applied Cognition, Department of Psychology, Faculty of Philosophy, University of Belgrade, 11000 Belgrade, Serbia.
Brain Sci. 2022 Sep 30;12(10):1332. doi: 10.3390/brainsci12101332.
A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.
无限制蔗糖摄入（USI）、超重与情绪/行为控制之间的潜在关系尚未得到充分记录。我们研究了USI以及甜度低于预期对成年C57BL/6J雄性小鼠体重（BW）、运动/探索行为、焦虑样行为和社会主导行为的影响。动物可自由获取水（第1组）或32%蔗糖溶液和水（蔗糖组2 - 5），持续10天。然后，第2组继续饮用32%蔗糖溶液，而第3 - 5组则经历蔗糖浓度下调（24小时可获取4%、8%或16%的蔗糖溶液）。所有实验组均进行称重，并在新奇开放场（NA）、高架十字迷宫（EPM）和管状试验中进行测试，分别评估BW、运动/探索行为、焦虑样行为和社会主导行为。USI并未影响动物的BW，但产生了多动和抗焦虑样行为，这在EPM中明显，但在NA中不明显；蔗糖浓度下调的结果与之相当。USI并未影响管状试验中的成功/获胜情况，但改变了驱动获胜的情绪，有利于产生焦虑程度较低的行为表型；这在蔗糖浓度下调的组中并不明显。观察结果表明，USI促进寻求刺激并激发主导性，而不改变BW，同时社会主导性的情绪基础减弱可能是蔗糖浓度下调的早期标志。
