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C57BL/6J 小鼠的杂交后代表现出改善的神经行为研究特性。

Hybrid Offspring of C57BL/6J Mice Exhibit Improved Properties for Neurobehavioral Research.

机构信息

Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

出版信息

eNeuro. 2022 Aug 17;9(4). doi: 10.1523/ENEURO.0221-22.2022. Print 2022 Jul-Aug.

DOI:10.1523/ENEURO.0221-22.2022
PMID:35906064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9395247/
Abstract

C57BL/6 is the most commonly used mouse strain in neurobehavioral research, serving as a background for multiple transgenic lines. However, C57BL/6 exhibit behavioral and sensorimotor disadvantages that worsen with age. We bred FVB/NJ females and C57BL/6J males to generate first-generation hybrid offspring (FVB/NJ x C57BL/6J)F1. The hybrid mice exhibit reduced anxiety-like behavior, improved learning, and enhanced long-term spatial memory. In contrast to both progenitors, hybrids maintain sensorimotor performance upon aging and exhibit improved long-term memory. The hybrids are larger than C57BL/6J, exhibiting enhanced running behavior on a linear track during freely-moving electrophysiological recordings. Hybrids exhibit typical rate and phase coding of space by CA1 pyramidal cells. Hybrids generated by crossing FVB/NJ females with transgenic males of a C57BL/6 background support optogenetic neuronal control in neocortex and hippocampus. The hybrid mice provide an improved model for neurobehavioral studies combining complex behavior, electrophysiology, and genetic tools readily available in C57BL/6 mice.

摘要

C57BL/6 是神经行为研究中最常用的小鼠品系，作为多个转基因品系的背景。然而，C57BL/6 表现出行为和感觉运动方面的劣势，随着年龄的增长而恶化。我们繁殖了 FVB/NJ 雌性和 C57BL/6J 雄性，以产生第一代杂交后代（FVB/NJ x C57BL/6J）F1。杂交小鼠表现出焦虑样行为减少、学习能力提高和长期空间记忆增强。与两个亲本相比，杂种在衰老时保持感觉运动性能，并表现出改善的长期记忆。杂种比 C57BL/6J 大，在自由移动的电生理记录中在线性轨道上表现出增强的奔跑行为。杂交小鼠的 CA1 锥体神经元表现出典型的空间频率和相位编码。通过将 FVB/NJ 雌性与 C57BL/6 背景的转基因雄性杂交产生的杂种支持新皮层和海马体中光遗传学神经元控制。杂种小鼠为神经行为研究提供了一个改进的模型，结合了 C57BL/6 小鼠中易于获得的复杂行为、电生理学和遗传工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/d1a87e902215/ENEURO.0221-22.2022_f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/1c9aa2166922/ENEURO.0221-22.2022_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/bd4270621d70/ENEURO.0221-22.2022_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/88728ac39f23/ENEURO.0221-22.2022_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/b9ba5e178cb1/ENEURO.0221-22.2022_f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/512c41a7e6e9/ENEURO.0221-22.2022_f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/d1a87e902215/ENEURO.0221-22.2022_f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/1c9aa2166922/ENEURO.0221-22.2022_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/bd4270621d70/ENEURO.0221-22.2022_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/88728ac39f23/ENEURO.0221-22.2022_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/b9ba5e178cb1/ENEURO.0221-22.2022_f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/512c41a7e6e9/ENEURO.0221-22.2022_f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ba/9395247/d1a87e902215/ENEURO.0221-22.2022_f006.jpg

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