Gaffney P R, Gleeson D J, Hall J W, Brady M P
Scand J Gastroenterol. 1987 Jun;22(5):525-32. doi: 10.3109/00365528708991892.
The results of pyloric manometric studies conflict, some showing evidence of a sphincter at the pylorus, others not: hence the term 'the fickle pylorus'. In this study we used perfused catheters to investigate the manometric properties of the human pylorus, in an attempt to explain the different results of similar experiments. A high-pressure zone (HPZ) of 5.9 mmHg (mean) was found at the pylorus in 53% of 170 measurements. The subjects' position had no effect on the HPZ, nor had duodenal acidification. Eating a meal increased the pressure from 5.0 mg Hg in the fasting state to 8.0 mm Hg after a meal. The results and those of 11 other manometric studies are considered; the evidence is against the presence of a tonic sphincter at the pylorus.
幽门测压研究的结果相互矛盾，一些研究显示幽门处存在括约肌的证据，而另一些则没有：因此有了“善变的幽门”这一说法。在本研究中，我们使用灌注导管来研究人体幽门的测压特性，试图解释类似实验的不同结果。在170次测量中，53%的测量发现在幽门处存在平均为5.9 mmHg的高压区（HPZ）。受试者的体位对HPZ没有影响，十二指肠酸化也没有影响。进食使压力从空腹状态下的5.0 mmHg增加到餐后的8.0 mmHg。我们考虑了这些结果以及其他11项测压研究的结果；证据表明幽门处不存在紧张性括约肌。
