Phaosawasdi K, Tolin R, Mayer E, Fisher R S
Dig Dis Sci. 1979 Dec;24(12):934-9. doi: 10.1007/BF01311949.
The effects of an intoxicating dose of alcohol (79 g of 100 proof alcohol) on pyloric sphincter function were studied in 12 normal subjects using an infused manometric system. Alcohol had no effect on resting pyloric sphincter pressure. Intraduodenal administration of olive oil and hypertonic amino acids increased pyloric sphincter pressure significantly to 10.8 +/- 1.4 and 10.2 +/- 2.0 mm Hg, respectively. These responses were not affected by the administration of alcohol. In contrast, alcohol decreased the pyloric pressure response to duodenal acidification from 12.0 +/- 2.1 to 8.0 +/- 1.3 mm Hg (P less than 0.05). These results suggest that an intoxicating dose of alcohol may interfere with the normal function of the pyloric sphincter.
使用灌注测压系统，在12名正常受试者中研究了中毒剂量酒精（79克100度酒精）对幽门括约肌功能的影响。酒精对静息幽门括约肌压力无影响。十二指肠内给予橄榄油和高渗氨基酸分别使幽门括约肌压力显著增加至10.8±1.4和10.2±2.0毫米汞柱。这些反应不受酒精给药的影响。相比之下，酒精使幽门对十二指肠酸化的压力反应从12.0±2.1毫米汞柱降至8.0±1.3毫米汞柱（P<0.05）。这些结果表明，中毒剂量的酒精可能会干扰幽门括约肌的正常功能。
