位于同步加速器PETRA III/DESY的白光束线P61A处的微束插入装置：一种用于高剂量率辐照研究的新工具。

The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research.

作者信息

Schültke Elisabeth, Fiedler Stefan, Mewes Catharina, Gargioni Elisabetta, Klingenberg Johannes, Abreu Faria Guilherme, Lerch Michael, Petasecca Marco, Prehn Franziska, Wegner Marie, Scholz Marten, Jaekel Felix, Hildebrandt Guido

机构信息

Department of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany.

European Molecular Biology Laboratory (EMBL), Hamburg Outstation, 22607 Hamburg, Germany.

出版信息

Cancers (Basel). 2022 Oct 20;14(20):5137. doi: 10.3390/cancers14205137.

DOI:10.3390/cancers14205137

PMID:36291920

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9600877/

Abstract

High dose rate radiotherapies such as FLASH and microbeam radiotherapy (MRT) both have developed to the stage of first veterinary studies within the last decade. With the development of a new research tool for high dose rate radiotherapy at the end station P61A of the synchrotron beamline P61 on the DESY campus in Hamburg, we increased the research capacity in this field to speed up the translation of the radiotherapy techniques which are still experimental, from bench to bedside. At P61, dose rates of several hundred Gy/s can be delivered. Compared to dedicated biomedical beamlines, the beam width available for MRT experiments is a very restrictive factor. We developed two model systems specifically to suit these specific technical parameters and tested them in a first set of experiments.

摘要

高剂量率放射疗法，如FLASH和微束放射疗法（MRT），在过去十年中都已发展到首次进行兽医研究的阶段。随着汉堡DESY园区同步加速器光束线P61终端站P61A处高剂量率放射疗法新研究工具的开发，我们提高了该领域的研究能力，以加速仍处于实验阶段的放射治疗技术从实验室到临床的转化。在P61，可以提供数百Gy/s的剂量率。与专门的生物医学光束线相比，可用于MRT实验的光束宽度是一个非常受限的因素。我们专门开发了两个模型系统以适应这些特定的技术参数，并在第一组实验中对它们进行了测试。