Korbmacher-Böttcher Dorina, Bamberg Fabian, Peters Annette, Linkohr Birgit, Ladwig Karl-Heinz, Schwettmann Lars, Weckbach Sabine, Schlett Christopher L, Rospleszcz Susanne
Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
Diagnostics (Basel). 2022 Sep 28;12(10):2356. doi: 10.3390/diagnostics12102356.
Management of radiological incidental findings (IF) is of rising importance; however, psychosocial implications of IF reporting remain unclear. We compared long-term psychosocial effects between individuals who underwent whole-body magnetic resonance imaging (MRI) with and without reported IF, and individuals who did not undergo imaging. We used a longitudinal population-based cohort from Western Europe. Longitudinal analysis included three examinations (exam 1, 6 years prior to MRI; exam 2, MRI; exam 3, 4 years after MRI). Psychosocial outcomes included PHQ-9 (Patient Health Questionnaire), DEEX (Depression and Exhaustion Scale), PSS-10 (Perceived Stress Scale) and a Somatization Scale. Univariate analyses and adjusted linear mixed models were calculated. Among 855 included individuals, 25% (n = 212) underwent MRI and 6% (n = 50) had at least one reported IF. Compared to MRI participants, non-participants had a higher psychosocial burden indicated by PHQ-9 in exam 1 (3.3 ± 3.3 vs. 2.5 ± 2.3) and DEEX (8.6 ± 4.7 vs. 7.7 ± 4.4), Somatization Scale (5.9 ± 4.3 vs. 4.8 ± 3.8) and PSS-10 (14.7 ± 5.7 vs. 13.7 ± 5.3, all p < 0.05) in exam 3. MRI participation without IF reporting was significantly associated with lower values of DEEX, PHQ-9 and Somatization Scale. There were no significant differences at the three timepoints between MRI participants with and without IF. In conclusion, individuals who voluntarily participated in whole-body MRI had less psychosocial burden and imaging and IF reporting were not associated with adverse long-term psychosocial consequences. However, due to the study design we cannot conclude that the MRI exam itself represented a beneficial intervention causing improvement in mental health scores.
放射学偶然发现（IF）的管理愈发重要；然而，IF报告的社会心理影响仍不明确。我们比较了接受全身磁共振成像（MRI）且报告了IF的个体、接受全身MRI但未报告IF的个体以及未接受成像检查的个体之间的长期社会心理影响。我们使用了来自西欧的基于人群的纵向队列。纵向分析包括三次检查（检查1，MRI前6年；检查2，MRI；检查3，MRI后4年）。社会心理结果包括PHQ-9（患者健康问卷）、DEEX（抑郁和疲惫量表）、PSS-10（感知压力量表）和躯体化量表。计算了单变量分析和调整后的线性混合模型。在纳入的855名个体中，25%（n = 212）接受了MRI检查，6%（n = 50）至少有一项报告的IF。与接受MRI检查的参与者相比，未参与者在检查1中的PHQ-9（3.3±3.3 vs. 2.5±2.3）、DEEX（8.6±4.7 vs. 7.7±4.4）、躯体化量表（5.9±4.3 vs. 4.8±3.8）和PSS-10（14.7±5.7 vs. 13.7±5.3，所有p < 0.05）显示出更高的社会心理负担。未报告IF的MRI参与者与较低的DEEX、PHQ-9和躯体化量表值显著相关。报告了IF和未报告IF的MRI参与者在三个时间点之间没有显著差异。总之，自愿参加全身MRI的个体社会心理负担较轻，成像和IF报告与不良的长期社会心理后果无关。然而，由于研究设计，我们不能得出MRI检查本身代表一种有益干预并导致心理健康评分改善的结论。
