Nassar Marwa A, Alsaadany Douaa S, Shaker Olfat G, El-Raheem Talal A Abd
Department of Dermatology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Al-Haud Al-Marsaud Hospital for Dermatology, Venereology and Andrology, Cairo, Egypt.
Arch Dermatol Res. 2025 Jan 18;317(1):289. doi: 10.1007/s00403-024-03776-6.
Vitiligo is considered as depigmenting skin disorder where patches of skin losing their pigment. Lipocalin-2 (LCN2) is one of the Inflammatory adipokines that has a potential role in skin disorders and other inflammatory diseases as well. To measure the concentration level of LCN2 in vitiligo patients compared to healthy controls and to investigate its relation to disease activity and other clinical data to evaluate its role in the pathogenesis of the disease. Eighty individuals subdivided equally into two groups (vitiligo and controls) were enrolled in the study. The serum level of LCN2 was measured by ELISA where from all participants, a 5-mL venous blood was withdrawn in plain tube from each subject. There were high significant difference of LCN2 in serum between both groups where LCN2 was higher in vitiligo patients than than controls with mean and standard deviations of 399.2 ± 134.6 and 257.2 ± 42.5 respectively (p < 0.001). The level of LCN2 tended to increase in vitiligo patients with sudden onset than gradual patients showing a significant difference with p-value 0.030. Regarding the severity of the disease results showed that the level of LCN2 tended to increase in moderate and severe patients than mild but with no significant difference between the groups. LCN2 may play a vital role and a good marker for the early diagnosis and the pathogenesis of vitiligo disease.
白癜风被认为是一种皮肤色素脱失性疾病，即皮肤斑块失去色素。脂质运载蛋白-2（LCN2）是一种炎症性脂肪因子，在皮肤疾病和其他炎症性疾病中也具有潜在作用。为了测量白癜风患者与健康对照者中LCN2的浓度水平，并研究其与疾病活动及其他临床数据的关系，以评估其在疾病发病机制中的作用。该研究纳入了80名个体，平均分为两组（白癜风组和对照组）。通过酶联免疫吸附测定法（ELISA）测量LCN2的血清水平，从所有参与者中，在普通试管中从每个受试者抽取5毫升静脉血。两组之间血清中LCN2存在高度显著差异，白癜风患者的LCN2高于对照组，其平均值和标准差分别为399.2±134.6和257.2±42.5（p<0.001）。白癜风突然发病患者的LCN2水平往往高于逐渐发病患者，p值为0.030，差异有统计学意义。关于疾病严重程度，结果显示中度和重度患者的LCN2水平往往高于轻度患者，但两组之间无显著差异。LCN2可能在白癜风疾病的早期诊断和发病机制中起重要作用且是一个良好的标志物。
