Colak S, Omma A, Sandikci S C, Yucel C, Omma T, Turhan T
Bratisl Lek Listy. 2019;120(1):65-69. doi: 10.4149/BLL_2019_010.
To examine the relationship between disease activity and vaspin, neutrophil gelatinase-associated lipocalin (NGAL) and apolipoprotein levels in patients with psoriatic arthritis (PsA).
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, which is related with psoriasis. Adipokines are the mediators which play a role in metabolic homeostasis and inflammatory conditions.
The levels of vaspin, NGAL, apolipoproteins and their correlations with disease activity were compared in 50 psoriatic arthritis patients and 36 healthy controls.
The levels of vaspin, NGAL and apolipoprotein B/A1 ratio were significantly higher in the patient group (p 0.05).
This is the first study to have compared vaspin and NGAL levels in patients with PsA. Vaspin and NGAL can be used as a biomarker in PsA. Vaspin, NGAL and dyslipoproteinemia are not correlated with disease activity (Tab. 3, Ref. 63).
研究银屑病关节炎（PsA）患者疾病活动度与内脏脂肪素、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）及载脂蛋白水平之间的关系。
银屑病关节炎（PsA）是一种与银屑病相关的慢性炎症性关节炎。脂肪因子是在代谢稳态和炎症状态中起作用的介质。
比较50例银屑病关节炎患者和36例健康对照者体内内脏脂肪素、NGAL、载脂蛋白水平及其与疾病活动度的相关性。
患者组内脏脂肪素、NGAL及载脂蛋白B/A1比值水平显著更高（p<0.05）。
这是第一项比较PsA患者内脏脂肪素和NGAL水平的研究。内脏脂肪素和NGAL可作为PsA的生物标志物。内脏脂肪素、NGAL和血脂异常与疾病活动度无关（表3，参考文献63）。
