Department of Human Biology, University of Haifa, Haifa 3498838, Israel.
Int J Mol Sci. 2022 Oct 21;23(20):12698. doi: 10.3390/ijms232012698.
Epigenetics modification such as DNA methylation can affect maternal health during the gestation period. Furthermore, pregnancy can drive a range of physiological and molecular changes that have the potential to contribute to pathological conditions. Pregnancy-related risk factors include multiple environmental, behavioral, and hereditary factors that can impact maternal DNA methylation with long-lasting consequences. Identification of the epigenetic patterns linked to poor pregnancy outcomes is crucial since changes in DNA methylation patterns can have long-term effects. In this review, we provide an overview of the epigenetic changes that influence pregnancy-related molecular programming such as gestational diabetes, immune response, and pre-eclampsia, in an effort to close the gap in current understanding regarding interactions between the environment, the genetics of the fetus, and the pregnant woman.
表观遗传修饰，如 DNA 甲基化，可能会影响妊娠期的母婴健康。此外，妊娠会引发一系列生理和分子变化，这些变化有可能导致病理状况。与妊娠相关的风险因素包括多种环境、行为和遗传因素，这些因素可能会影响母体的 DNA 甲基化，并产生持久的后果。识别与不良妊娠结局相关的表观遗传模式至关重要，因为 DNA 甲基化模式的改变可能会产生长期影响。在这篇综述中，我们概述了影响妊娠相关分子编程的表观遗传变化，如妊娠糖尿病、免疫反应和子痫前期，以努力缩小目前对环境、胎儿遗传和孕妇之间相互作用的理解差距。
