Center for Family Research, The University of Georgia, Athens, GA 30602, USA.
Department of Psychology, The University of Georgia, Athens, GA 30602, USA.
Int J Environ Res Public Health. 2022 Oct 17;19(20):13421. doi: 10.3390/ijerph192013421.
In a sample of 685 late middle-aged Black adults (M age at 2019 = 57.17 years), we examined the effects of loneliness and per capita income on accelerated aging using a newly developed DNA-methylation based index: the DunedinPACE. First, using linear, mixed effects regression in a growth curve framework, we found that change in DunedinPACE was dependent on age, with a linear model best fitting the data (b = 0.004, < 0.001), indicating that average pace of change increased among older participants. A quadratic effect was also tested, but was non-significant. Beyond the effect of age, both change in loneliness (b = 0.009, < 0.05) and change in per capita income (b = -0.016, < 0.001) were significantly associated with change in DunedinPACE across an 11-year period, accounting for significant between person variability observed in the unconditional model. Including non-self-report indices of smoking and alcohol use did not reduce the association of loneliness or per capita income with DunedinPACE. However, change in smoking was strongly associated with change in DunedinPACE such that those reducing their smoking aged less rapidly than those continuing to smoke. In addition, both loneliness and per capita income were associated with DunedinPACE after controlling for variation in cell-types.
在一项由 685 名中老年黑人成年人组成的样本中（2019 年的平均年龄为 57.17 岁），我们使用新开发的基于 DNA 甲基化的指数：DunedinPACE，研究了孤独感和人均收入对加速衰老的影响。首先，我们在增长曲线框架中使用线性混合效应回归，发现 DunedinPACE 的变化取决于年龄，线性模型最适合数据（b=0.004，<0.001），这表明随着年龄的增长，参与者的平均变化速度加快。还测试了二次效应，但不显著。除了年龄的影响外，孤独感的变化（b=0.009，<0.05）和人均收入的变化（b=-0.016，<0.001）与 DunedinPACE 在 11 年期间的变化显著相关，这解释了在无条件模型中观察到的个体间显著的可变性。包括吸烟和饮酒的非自我报告指数并不会降低孤独感或人均收入与 DunedinPACE 之间的关联。然而，吸烟的变化与 DunedinPACE 的变化密切相关，那些减少吸烟的人比继续吸烟的人衰老得更慢。此外，在控制细胞类型变化的情况下，孤独感和人均收入都与 DunedinPACE 有关。
