Putra Handityo Aulia, Park Kaechang, Yamashita Fumio
Research Organization for Regional Alliances, Kochi University of Technology, Kochi 782-8502, Japan.
Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
J Clin Med. 2022 Oct 13;11(20):6037. doi: 10.3390/jcm11206037.
The relationship between fatigue perception and regional gray matter volume (rGMV) has seldom been studied in healthy adults. Therefore, this study aimed to analyze sex differences in the correlation between rGMV and fatigue perception using Chalder's fatigue questionnaire (CFQ). The CFQ was used to analyze the sexual features of rGMV related to the degree of perceived fatigue in 2955 healthy adults (male = 1560, female = 1395) of various ages (20-89 years, median 56). A higher CFQ score denotes a higher perceived fatigue level by the participant. According to the CFQ scores in males, the volumes of the right orbital part of the inferior frontal gyrus and left precuneus were negatively correlated (i.e., smaller rGMV had a higher CFQ score), whereas the left angular gyrus was positively correlated. In females, the right inferior temporal gyrus was negative, whereas the left middle temporal gyrus and right putamen were positive (i.e., larger rGMV had a higher CFQ score). The lack of identified regions in this large-scale study between males and females might be related to sex differences in clinical or pathological fatigue morbidities. Additionally, the sex differences in the negative or positive correlations between rGMV and fatigue perception may contribute to a better understanding of the neuronal mechanism in the early stages of fatigue development.
在健康成年人中，疲劳感知与局部灰质体积（rGMV）之间的关系鲜有研究。因此，本研究旨在使用查尔德疲劳问卷（CFQ）分析rGMV与疲劳感知之间相关性的性别差异。CFQ用于分析2955名不同年龄（20 - 89岁，中位数56岁）的健康成年人（男性 = 1560，女性 = 1395）中与疲劳感知程度相关的rGMV的性别特征。CFQ得分越高表明参与者的疲劳感知水平越高。根据男性的CFQ得分，额下回右侧眶部和左侧楔前叶的体积呈负相关（即rGMV越小，CFQ得分越高），而左侧角回呈正相关。在女性中，右侧颞下回呈负相关，而左侧颞中回和右侧壳核呈正相关（即rGMV越大，CFQ得分越高）。在这项大规模研究中，男性和女性未发现相同的脑区，这可能与临床或病理性疲劳发病率的性别差异有关。此外，rGMV与疲劳感知之间正负相关性的性别差异可能有助于更好地理解疲劳发展早期的神经元机制。
