Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, England, UK.
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Scotland, UK.
Neuroimage Clin. 2017 Sep 28;17:24-30. doi: 10.1016/j.nicl.2017.09.024. eCollection 2018.
Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods.
Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments.
Accounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe.
Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem.
利用磁共振成像（MRI）和最新的基于体素的形态测量学（VBM）方法，研究慢性疲劳综合征（CFS）患者的全脑和灰白质体积。
对 42 名 CFS 患者和 30 名健康志愿者在 3T 磁共振扫描仪上进行扫描。对解剖学 MRI 扫描进行分割、归一化，并使用随机化方法进行 VBM 分析。在总体节段体积和体素化的灰质（GM）和白质（WM）节段中，确定了组间差异。
考虑到总颅内体积，患者的 GM 体积较大，WM 体积较小。体素分析显示，患者组的多个结构中 GM 体积增加，包括杏仁核和岛叶。患者组 WM 体积减少主要见于中脑、脑桥和右侧颞叶。
CFS 患者的 GM 体积升高见于与处理内脏信号和应激相关的区域。患者组 WM 体积减少部分支持了以前关于中脑和脑干区域 WM 异常的发现。
