Adam Ana-Maria, Vasilache Ingrid-Andrada, Socolov Demetra, Stuparu Cretu Mariana, Georgescu Costinela Valerica, Vicoveanu Petronela, Mihalceanu Elena, Harabor Anamaria, Socolov Razvan
Clinical and Surgical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800216 Galati, Romania.
Department of Obstetrics and Gynecology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
J Clin Med. 2022 Oct 13;11(20):6055. doi: 10.3390/jcm11206055.
(1) Background: Pregnant patients with severe forms of coronavirus disease 2019 (COVID-19) can experience adverse pregnancy outcomes. The aim of this study was to retrospectively assess the risk factors associated with admission to the intensive care unit (ICU) of pregnant patients with COVID-19, as well as the pregnancy outcomes of these patients; (2) Methods: Medical records of 31 pregnant patients with COVID-19 admitted to three clinical hospitals from Romania, between October 2020 and November 2021 were examined. The patients were segregated into two groups depending on their clinical evolution: non-ICU admission ( = 19) or ICU admission ( = 12). Clinical and paraclinical findings were evaluated using univariate analysis, and the association of significant risk factors with maternal ICU admission was assessed using a multivariate analysis. Pregnancy outcomes of these patients were also recorded; (3) Results: Pulmonary disease, cough, dyspnea, leukocytosis, thrombocytosis, high serum values of transaminases, serum ferritin, and increased duration of hospital admission were identified as significant risk factors associated with maternal admission to the ICU. No significant differences regarding pregnancy outcomes were noted between the evaluated patients; (4) Conclusions: Specific risk factor identification in pregnant patients with severe forms of COVID-19 could improve the patient's management.
(1) 背景：患有重症2019冠状病毒病（COVID-19）的孕妇可能会出现不良妊娠结局。本研究的目的是回顾性评估COVID-19孕妇入住重症监护病房（ICU）的相关危险因素以及这些患者的妊娠结局；(2) 方法：对2020年10月至2021年11月期间罗马尼亚三家临床医院收治的31例COVID-19孕妇的病历进行检查。根据临床病程将患者分为两组：非ICU入院组（n = 19）或ICU入院组（n = 12）。采用单因素分析评估临床和辅助检查结果，并采用多因素分析评估显著危险因素与产妇入住ICU的相关性。还记录了这些患者的妊娠结局；(3) 结果：肺部疾病、咳嗽、呼吸困难、白细胞增多、血小板增多、转氨酶、血清铁蛋白血清值升高以及住院时间延长被确定为与产妇入住ICU相关的显著危险因素。在评估的患者之间，妊娠结局未发现显著差异；(4) 结论：识别重症COVID-19孕妇的特定危险因素可改善患者管理。
