Lai Wei-Yu, Lin Pei-Chin, Yin Chun-Hao, Yang Kuang-Tsu, Shih En-Jie, Chen Jin-Shuen
Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
J Clin Med. 2022 Oct 17;11(20):6116. doi: 10.3390/jcm11206116.
Retinal artery occlusion (RAO) is most commonly caused by embolism. Evidence showed that hematocrit (Hct) levels are often associated with embolic events. In this study, we aim to investigate the relationship between Hct levels and RAO. This retrospective study enrolled RAO patients between January 2011 and March 2020, who were 1:4 matched by age, gender, index date, and relevant comorbidities with the non-RAO group. Patient characteristics and laboratory data were collected. Univariate conditional logistic regression was applied by estimating crude matched odds ratios to determine the relevant factors for the occurrence of RAO. Furthermore, a narrative review of the relevant study was conducted to explore the association between Hct levels and embolism. Between January 2011 to March 2020, 82 RAO patients and 328 non-RAO patients matched with age, gender, index date, comorbidities of hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, stroke, and atrial fibrillation were enrolled after excluding ineligible individuals. Conditional logistic regression analysis showed that Hct level ≥ 40% was associated with developing RAO. A forest plot showed a trend of a non-linear dose-response association between Hct levels and ischemic vascular events in male patients. Hct levels ≥ 40% in patients older than 65 years with at least six comorbidities could be associated with RAO. We suggest that older patients who have multiple comorbidities, combined with elevated Hct levels, should be informed of the possible occurrence of RAO.
视网膜动脉阻塞（RAO）最常见的病因是栓塞。有证据表明，血细胞比容（Hct）水平常与栓塞事件相关。在本研究中，我们旨在调查Hct水平与RAO之间的关系。这项回顾性研究纳入了2011年1月至2020年3月期间的RAO患者，这些患者在年龄、性别、索引日期和相关合并症方面与非RAO组按1:4进行匹配。收集了患者的特征和实验室数据。通过估计粗匹配比值比应用单变量条件逻辑回归来确定RAO发生的相关因素。此外，对相关研究进行了叙述性综述，以探讨Hct水平与栓塞之间的关联。在2011年1月至2020年3月期间，排除不符合条件的个体后，纳入了82例RAO患者和328例在年龄、性别、索引日期、高血压、糖尿病、血脂异常、慢性肾脏病、中风和心房颤动合并症方面相匹配的非RAO患者。条件逻辑回归分析表明，Hct水平≥40%与发生RAO相关。森林图显示男性患者中Hct水平与缺血性血管事件之间存在非线性剂量反应关联趋势。65岁以上且至少有六种合并症的患者中，Hct水平≥40%可能与RAO相关。我们建议，对于有多种合并症且Hct水平升高的老年患者，应告知其可能发生RAO。
