Huin Marine, Lorenzini Jerome, Arbion Flavie, Carcopino Xavier, Touboul Cyril, Dabi Yohann, Kerbage Yohan, Costaz Hélène, Lecointre Lise, Lavoué Vincent, Bolze Pierre-Adrien, Huchon Cyrille, Bricou Alexandre, Canlorbe Geoffroy, Mimoun Camille, Bendifallah Sofiane, Gauthier Tristan, Body Gilles, Ouldamer Lobna
Department of Gynecology, Tours University Hospital, 37044 Tours, France.
INSERM U1069, Université François-Rabelais, 37044 Tours, France.
J Clin Med. 2022 Oct 17;11(20):6120. doi: 10.3390/jcm11206120.
The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. This was a descriptive, retrospective, multicenter study conducted in 13 French centres from 1 January 2001 to 31 December 2019. All patients operated on for epithelial ovarian neoplasia of the mucinous type (infiltrative/expansile) were included, whether the surgery was performed immediately or after neoadjuvant chemotherapy. A total of 94 women with mucinous carcinomas were included in the present study. Mucinous tumours were divided into 35 expansile (37%) and 59 infiltrative (63%) mOC. There was a statistically significant difference in early and late stages at initial diagnosis between expansile and infiltrative mOC. None of the expansile mOC showed metastatic lymph nodes, whereas almost a quarter of the infiltrative mOC were metastatic to the pelvic/para-aortic region. There was a clear difference in RFS, in favour of expansile mOC, with 90% survival at 5 years, compared with 60% for infiltrative mOC. Although infiltrative and expansile mOC belong to the same histological family, they present many distinctions in clinical presentation, histological invasion, and disease course.
本研究的目的是评估黏液性卵巢癌（mOC）在两种浸润模式（膨胀性浸润和浸润性浸润）方面的演变和预后。这是一项描述性、回顾性、多中心研究，于2001年1月1日至2019年12月31日在法国的13个中心进行。所有接受黏液性上皮性卵巢肿瘤（浸润性/膨胀性）手术的患者均被纳入，无论手术是立即进行还是在新辅助化疗后进行。本研究共纳入94例黏液性癌女性患者。黏液性肿瘤分为35例膨胀性mOC（37%）和59例浸润性mOC（63%）。膨胀性和浸润性mOC在初诊时的早期和晚期阶段存在统计学显著差异。膨胀性mOC均未显示有转移淋巴结，而近四分之一的浸润性mOC转移至盆腔/腹主动脉旁区域。无进展生存期（RFS）存在明显差异，膨胀性mOC更具优势，5年生存率为90%，而浸润性mOC为60%。尽管浸润性和膨胀性mOC属于同一组织学类型，但它们在临床表现、组织学浸润和病程方面存在许多差异。
