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硬膜外镇痛对罗布森分类法1、2a、3和4a类分娩及母婴结局的影响:一项倾向评分匹配分析

The Effect of Epidural Analgesia on Labour and Neonatal and Maternal Outcomes in 1, 2a, 3, and 4a Robson's Classes: A Propensity Score-Matched Analysis.

作者信息

Zanfini Bruno Antonio, Catarci Stefano, Vassalli Francesco, Laurita Longo Valentina, Biancone Matteo, Carducci Brigida, Frassanito Luciano, Lanzone Antonio, Draisci Gaetano

机构信息

Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Largo A Gemelli 8, 00168 Roma, Italy.

Obstetric Anesthesia, Department of Critical Care and Perinatal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Giannina Gaslini, 16147 Genova, Italy.

出版信息

J Clin Med. 2022 Oct 18;11(20):6124. doi: 10.3390/jcm11206124.

Abstract

Background: Lumbar epidural analgesia (EA) is the most commonly used method for reducing labour pain, but its impact on the duration of the second stage of labour and on neonatal and maternal outcomes remains a matter of debate. Our aim was to examine whether EA affected the course and the outcomes of labour among patients divided according to the Robson-10 group classification system. Methods: Patients of Robson’s classes 1, 2a, 3, and 4a were divided into either the EA group or the non-epidural analgesia (NEA) group. A propensity score-matching analysis was performed to balance the intergroup differences. The primary goal was to analyse the duration of the second stage of labour. The secondary goals were to evaluate neonatal and maternal outcomes. Results: In total, 21,808 cases were analysed. The second stage of labour for all groups was prolonged using EA (p < 0.05) without statistically significant differences in neonatal outcomes. EA resulted in a lower rate of episiotomies in nulliparous patients, with a higher rate of operative vaginal deliveries (OVD) (p < 0.05) and Caesarean sections (CS) (p < 0.05) in some classes. Conclusions: EA prolonged the duration of labour without affecting neonatal outcomes and reduced the rate of episiotomies, but also increased the rate of OVDs.

摘要

背景

腰椎硬膜外镇痛(EA)是减轻分娩疼痛最常用的方法,但其对第二产程时长以及新生儿和产妇结局的影响仍存在争议。我们的目的是研究在根据罗布森-10组分类系统划分的患者中,EA是否会影响分娩过程和结局。方法:罗布森分类1、2a、3和4a类的患者被分为EA组或非硬膜外镇痛(NEA)组。进行倾向评分匹配分析以平衡组间差异。主要目标是分析第二产程的时长。次要目标是评估新生儿和产妇结局。结果:总共分析了21,808例病例。使用EA使所有组的第二产程延长(p<0.05),新生儿结局无统计学显著差异。EA导致初产妇会阴切开率较低,在某些类别中手术阴道分娩(OVD)率(p<0.05)和剖宫产(CS)率(p<0.05)较高。结论:EA延长了产程,不影响新生儿结局,降低了会阴切开率,但也增加了OVD率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d47/9604843/4b7a11432ec9/jcm-11-06124-g001.jpg

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