Taniguchi Yoshiaki, Makizako Hyuma, Nakai Yuki, Kiuchi Yuto, Akaida Shoma, Tateishi Mana, Takenaka Toshihiko, Kubozono Takuro, Ohishi Mitsuru
Graduate School of Health Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Department of Physical Therapy, Kagoshima Medical Professional College, Kagoshima 891-0133, Japan.
J Clin Med. 2022 Oct 19;11(20):6172. doi: 10.3390/jcm11206172.
Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05−8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.
已知骨量和肌肉量的流失会同时发生。α-辅肌动蛋白3（ACTN3）基因型已被证明可能影响骨量和肌肉量。在本研究中，我们调查了≥60岁社区居住成年人中ACTN3基因型与骨量和肌肉量流失之间的关联。本研究是对295名参加社区健康检查的参与者的数据进行的横断面分析。ACTN3基因型被分为RR、RX或XX型。骨量流失定义为跟骨超声速度T值<−1.32和<−1.37，肌肉量流失分别定义为男性和女性的四肢骨骼肌指数<7.0 kg/m2和<5.7 kg/m2。在合并的骨量和肌肉量流失组中，XX、RX和RR的比例分别为33.8%、30.8%和16.7%，XX型有显著更高的趋势。多项逻辑回归分析显示，与RR组相比，XX型在合并的骨量和肌肉量流失组中的优势比为3.00（95%置信区间1.05−8.54）（协变量：年龄、性别、握力和药物）。XX型ACTN3基因型与更高的骨量和肌肉量合并流失率相关。因此，为预防骨量和肌肉量合并流失，应考虑进行ACTN3基因分型。
