College of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea.
Biomed Res Int. 2017;2017:4239648. doi: 10.1155/2017/4239648. Epub 2017 May 24.
Little information is available about molecular markers for sarcopenia and osteoporosis in Asian populations.
This study investigated the association of the polymorphism with sarcopenia and osteoporotic status in older Korean adults.
Older Korean 62 men and 270 women (mean age 73.7 ± 6.6 years) participated in this study. Body mass index, percent body fatness, appendicular skeletal muscle mass, and bone mineral density of the lumbar spine, femur, and total body were analyzed with dual-energy X-ray absorptiometry. R/X genotyping was determined using TaqMan probes.
Determination of odds ratios (ORs) and 95% confidence intervals (CIs) using binary logistic regression analyses showed that XX homozygotes were at a significantly higher risk of sarcopenia (OR = 2.056, 95% CI = 1.024-4.127, = 0.043) and osteoporosis (OR = 2.794, 95% CI = 1.208-5.461, = 0.016) than RR homozygotes (reference group, OR = 1). The OR of XX homozygotes for having sarcopenia remained significant (OR = 2.237, 95% CI = 1.044-4.836, = 0.038) after adjustments for age, gender, body fatness, and serum vitamin D. The OR of XX homozygotes for having osteoporosis was no longer significant (OR = 2.682, 95% CI = 0.960-7.942, = 0.075) after adjustments for the covariates.
Our findings suggest that the R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults.
亚洲人群中，关于肌少症和骨质疏松症的分子标志物的信息较少。
本研究旨在探讨韩国老年人中 R577X 多态性与肌少症和骨质疏松症状态的关系。
本研究纳入了 62 名男性和 270 名女性（平均年龄 73.7 ± 6.6 岁）。使用双能 X 射线吸收法分析了身体质量指数、体脂百分比、四肢骨骼肌质量以及腰椎、股骨和全身的骨矿物质密度。采用 TaqMan 探针法确定 R/X 基因型。
使用二元逻辑回归分析确定比值比（OR）和 95%置信区间（CI）显示，XX 纯合子发生肌少症的风险显著升高（OR=2.056，95%CI=1.024-4.127，=0.043）和骨质疏松症（OR=2.794，95%CI=1.208-5.461，=0.016）的风险明显高于 RR 纯合子（参考组，OR=1）。XX 纯合子发生肌少症的 OR 在调整年龄、性别、体脂和血清维生素 D 后仍具有显著性（OR=2.237，95%CI=1.044-4.836，=0.038）。XX 纯合子发生骨质疏松症的 OR 在调整协变量后不再具有显著性（OR=2.682，95%CI=0.960-7.942，=0.075）。
我们的研究结果表明，R577X 基因型可能影响韩国老年人肌肉和骨骼健康表型的下降。
