Mendoza-García Sara, García-Mieres Helena, Lopez-Carrilero Raquel, Sevilla-Lewellyn-Jones Julia, Birulés Irene, Barajas Ana, Lorente-Rovira Ester, Gutiérrez-Zotes Alfonso, Grasa Eva, Pousa Esther, Pelaéz Trini, Barrigón Maria Luisa, González-Higueras Fermin, Ruiz-Delgado Isabel, Cid Jordi, Montserrat Roger, Martin-Iñigo Laia, Moreno-Kustner Berta, Vila-Bbadía Regina, Díaz-Cutraro Luciana, Verdaguer-Rodríguez Marina, Ferrer-Quintero Marta, Punsoda-Puche Paola, Barrau-Sastre Paula, Moritz Steffen, Ochoa Susana
Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, Spain.
Facultad de Psicología, Universidad de Barcelona, 08035 Barcelona, Spain.
J Pers Med. 2022 Oct 18;12(10):1732. doi: 10.3390/jpm12101732.
This study investigates, for the first time, clinical, cognitive, social cognitive and metacognitive differences in people diagnosed with first-episode of psychosis (FEP) with and without a family history of mental disorder split by maternal and paternal antecedents. A total of 186 individuals with FEP between 18 and 45 years old were recruited in community mental-health services. A transversal, descriptive, observational design was chosen for this study. Results suggest that there is a higher prevalence of maternal history of psychosis rather than paternal, and furthermore, these individuals exhibit a specific clinical, social and metacognitive profile. Individuals with a maternal history of mental disorder scored higher in delusional experiences, inhibition of the response to a stimulus and higher emotional irresponsibility while presenting a poorer overall functioning as compared to individuals without maternal history. Individuals with paternal history of mental disorder score higher in externalizing attributional bias, irrational beliefs of need for external validation and high expectations. This study elucidates different profiles of persons with FEP and the influence of the maternal and paternal family history on clinical, cognitive, social and metacognitive variables, which should be taken into account when offering individualized early treatment.
本研究首次调查了有和没有精神障碍家族史（按母系和父系祖先划分）的首次发作精神病（FEP）患者在临床、认知、社会认知和元认知方面的差异。在社区心理健康服务机构招募了186名年龄在18至45岁之间的FEP患者。本研究采用横断面、描述性、观察性设计。结果表明，有精神病家族史的情况在母系中比在父系中更为普遍，此外，这些个体表现出特定的临床、社会和元认知特征。与没有母系精神障碍家族史的个体相比，有母系精神障碍家族史的个体在妄想体验、对刺激反应的抑制以及更高的情感不负责任方面得分更高，同时整体功能较差。有父系精神障碍家族史的个体在外显归因偏差、对外部验证需求的非理性信念和高期望方面得分更高。本研究阐明了FEP患者的不同特征以及母系和父系家族史对临床、认知、社会和元认知变量的影响，在提供个体化早期治疗时应考虑这些因素。
