Mekky Radwa Y, Elemam Noha M, Eltahtawy Omar, Zeinelabdeen Yousra, Youness Rana A
Department of Pharmacology and Toxicology, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA University), Cairo 12622, Egypt.
Sharjah Institute for Medical Research (SIMR), College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Life (Basel). 2022 Oct 20;12(10):1654. doi: 10.3390/life12101654.
COVID-19 is a recent pandemic that mandated the scientific society to provide effective evidence-based therapeutic approaches for the prevention and treatment for such a global threat, especially to those patients who hold a higher risk of infection and complications, such as patients with autoimmune diseases and cancer. Recent research has examined the role of various fat-soluble vitamins (vitamins A, D, E, and K) in reducing the severity of COVID-19 infection. Studies showed that deficiency in fat-soluble vitamins abrogates the immune system, thus rendering individuals more susceptible to COVID-19 infection. Moreover, another line of evidence showed that supplementation of fat-soluble vitamins during the course of infection enhances the viral clearance episode by promoting an adequate immune response. However, more thorough research is needed to define the adequate use of vitamin supplements in cancer and autoimmune patients infected with COVID-19. Moreover, it is crucial to highlight the vitamin-drug interactions of the COVID-19 therapeutic modalities and fat-soluble vitamins. With an emphasis on cancer and autoimmune patients, the current review aims to clarify the role of fat-soluble vitamins in SARS-CoV-2 infection and to estimate the risk-to-benefit ratio of a fat-soluble supplement administered to patients taking FDA-approved COVID-19 medications such as antivirals, anti-inflammatory, receptor blockers, and monoclonal antibodies.
新型冠状病毒肺炎（COVID-19）是一种近期出现的大流行病，它要求科学界提供基于有效证据的治疗方法，以预防和治疗这种全球威胁，特别是针对那些感染和出现并发症风险较高的患者，如自身免疫性疾病患者和癌症患者。最近的研究探讨了各种脂溶性维生素（维生素A、D、E和K）在减轻COVID-19感染严重程度方面的作用。研究表明，脂溶性维生素缺乏会损害免疫系统，从而使个体更容易感染COVID-19。此外，另一系列证据表明，在感染过程中补充脂溶性维生素可通过促进适当的免疫反应来增强病毒清除过程。然而，需要更深入的研究来确定在感染COVID-19的癌症和自身免疫性疾病患者中维生素补充剂的合理使用。此外，突出COVID-19治疗方式与脂溶性维生素之间的维生素-药物相互作用至关重要。以癌症和自身免疫性疾病患者为重点，本综述旨在阐明脂溶性维生素在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染中的作用，并评估给服用美国食品药品监督管理局（FDA）批准的COVID-19药物（如抗病毒药物、抗炎药、受体阻滞剂和单克隆抗体）的患者服用脂溶性补充剂的风险效益比。
