Koimtzis Georgios, Stefanopoulos Leandros, Brooker Verity, Geropoulos Georgios, Chalklin Christopher G, Gupta Sapna, Carrington-Windo Eliot, Papaioannou Maria, Papavramidis Theodosios S
Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK.
Lab of Computing, Medical Informatics and Biomedical Imaging Technologies, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Life (Basel). 2022 Oct 20;12(10):1664. doi: 10.3390/life12101664.
The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray literature. Ultimately, 16 articles with an average of 255.75 patients were included in this review. These articles compared the long-term outcomes of vitamin D deficiency and/or vitamin D supplementation therapy on kidney transplant recipients by assessing various parameters. Most of the included studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate. We suggest that patients awaiting kidney transplantation have a careful evaluation in order to assess their vitamin D status and the optimal supplementation therapy. Regular follow-up of vitamin D levels post-transplant is also suggested. Prospective studies will be needed to establish the positive effects of vitamin D supplementation therapy on kidney transplant outcomes.
本系统评价的目的是评估维生素D对肾移植结局的影响，并调查维生素D缺乏是否与负面影响相关。我们在PubMed、Scopus和Cochrane数据库以及灰色文献中进行了系统的文献检索。最终，本评价纳入了16篇文章，平均涉及255.75例患者。这些文章通过评估各种参数，比较了维生素D缺乏和/或维生素D补充治疗对肾移植受者的长期结局。大多数纳入研究表明，维生素D缺乏与肾移植的不良影响相关，表现为移植肾功能较差、急性排斥反应发生率较高、蛋白尿发生率较高以及移植肾和患者总体生存率较低。我们建议，等待肾移植的患者应进行仔细评估，以评估其维生素D状态和最佳补充治疗方案。还建议在移植后定期随访维生素D水平。需要进行前瞻性研究，以确定维生素D补充治疗对肾移植结局的积极影响。
