Regañón E, Vila V, Aznar J, Garrido G, Estellés A, Berenguer J
Thromb Res. 1987 Jun 1;46(5):705-14. doi: 10.1016/0049-3848(87)90272-6.
Alterations in the coagulation system are common in patients with liver disease. We have examined the importance of the species and chains of fibrinogen in 3 groups of cirrhotic patients. The study of the gelation of fibrinogen in cirrhotic patients shows that the lag time increases in 80.3% of them and that the maximum gelation rate is altered in 51% of these plasmas. Also it is observed that 80% of the plasmas from cirrhotic patients have a percentage (23.3 +/- 7.7%) of unpolymerized alpha chain, after highly cross-linked fibrin formation. These alterations, in lag time and in the maximum gelation rate, have no significant correlation with the situation of the fibrinolytic system in these patients. The study of isolated fibrinogen from cirrhotic patients and normal subjects plasma, shows that there are no objective alterations in the percentage of fibrinogen species, the amount of sialic acid or the ratio of polypeptide chains.
凝血系统的改变在肝病患者中很常见。我们研究了3组肝硬化患者中纤维蛋白原的种类和链的重要性。对肝硬化患者纤维蛋白原凝胶化的研究表明，其中80.3%的患者延迟时间增加，且这些血浆中有51%的最大凝胶化速率发生改变。还观察到，在高度交联的纤维蛋白形成后，80%的肝硬化患者血浆中有一定比例（23.3±7.7%）的未聚合α链。这些延迟时间和最大凝胶化速率的改变与这些患者纤溶系统的状况无显著相关性。对肝硬化患者和正常受试者血浆中分离出的纤维蛋白原的研究表明，纤维蛋白原种类的百分比、唾液酸含量或多肽链比例没有客观改变。
