Cardiology Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Medicina (Kaunas). 2022 Sep 21;58(10):1319. doi: 10.3390/medicina58101319.
In clinical practice, we observed that the prognoses of patients with heart failure and atrial fibrillation were worse than those of patients with only heart failure or atrial fibrillation. The study aims to get a better understanding of the common pathogenesis of the two diseases and find new therapeutic targets. We downloaded heart failure datasets and atrial fibrillation datasets from the gene expression omnibus database. The common DEGs (differentially expressed genes) in heart failure and atrial fibrillation were identified by a series of bioinformatics methods. To better understand the functions and possible pathways of DEGs, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. We identified 22 up-regulated genes and 14 down-regulated genes in two datasets of heart failure and 475 up-regulated and 110 down-regulated genes in atrial fibrillation datasets. In addition, two co-upregulated (FRZB, SFRP4) and three co-downregulated genes (ENTPPL, AQP4, C1orf105) were identified. GO enrichment results showed that these common differentially expressed genes were mainly concentrated in the signal regulation of the Wnt pathway. We found five crucial genes in heart failure and atrial fibrillation, which may be potential therapeutic targets for patients with heart failure and atrial fibrillation.
在临床实践中，我们观察到心力衰竭合并心房颤动患者的预后比单纯心力衰竭或心房颤动患者差。本研究旨在更好地了解这两种疾病的共同发病机制，并寻找新的治疗靶点。
我们从基因表达综合数据库中下载了心力衰竭数据集和心房颤动数据集。通过一系列生物信息学方法，确定了心力衰竭和心房颤动中共有的差异表达基因（DEGs）。为了更好地了解 DEGs 的功能和可能的途径，我们进行了基因本体（GO）和京都基因与基因组百科全书（KEGG）分析。
我们在心力衰竭的两个数据集和心房颤动数据集中分别鉴定出 22 个上调基因和 14 个下调基因，以及 475 个上调基因和 110 个下调基因。此外，还鉴定出两个共同上调基因（FRZB、SFRP4）和三个共同下调基因（ENTPPL、AQP4、C1orf105）。GO 富集结果表明，这些共同差异表达基因主要集中在 Wnt 通路的信号调节中。
我们发现了心力衰竭和心房颤动中的五个关键基因，它们可能是心力衰竭和心房颤动患者的潜在治疗靶点。
