Bieber A L, McParland R H, Becker R R
Toxicon. 1987;25(6):677-80. doi: 10.1016/0041-0101(87)90115-2.
Myotoxins I and II were isolated from the venom of Crotalus viridis concolor. Complete sequences were derived for each reduced, alkylated toxin with data obtained by a single run on a gas phase sequencer and from fragments derived by cyanogen bromide cleavage. The results demonstrate that microheterogeneity is present in myotoxin II. The newly established sequences were compared with 3447 protein sequences in the Protein Information Resource database. The only homologous proteins found were other known myotoxins from rattlesnake venoms, namely myotoxin a, crotamine and peptide C.
肌毒素I和II是从草原响尾蛇（Crotalus viridis concolor）的毒液中分离出来的。通过在气相测序仪上单次运行获得的数据以及溴化氰裂解产生的片段，推导出了每种还原、烷基化毒素的完整序列。结果表明，肌毒素II存在微观异质性。将新确定的序列与蛋白质信息资源数据库中的3447个蛋白质序列进行了比较。发现的唯一同源蛋白质是来自响尾蛇毒液的其他已知肌毒素，即肌毒素a、响尾蛇胺和肽C。
