Flores-García Diana Laura, Aguilar-Díaz Hugo, Amaro-Estrada Itzel, Martínez-Ocampo Fernando, Quiroz-Castañeda Rosa Estela
Departamento de Ingeniería en Biotecnología, Universidad Politécnica del Estado de Morelos, Paseo Cuauhnahuac 566, Lomas del Texcal, C.P., Jiutepec 62574, Morelos, Mexico.
Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Carretera Federal Cuernavaca-Cuautla No. 8534, Col. Progreso, Jiutepec 62550, Morelos, Mexico.
Microorganisms. 2022 Sep 27;10(10):1916. doi: 10.3390/microorganisms10101916.
and ' Mycoplasma haemobos' are bacteria that have been described as significant hemoplasmas that infect cattle worldwide. Currently, three bovine hemoplasma genomes are known. This work aimed to describe the main genomic characteristics and the evolutionary relationships between hemoplasmas, and provide a list of epitopes predicted by immunoinformatics as diagnostic candidates for bovine hemoplasmosis. Thus far, there is no vaccine to prevent this disease that economically impacts cattle production worldwide. Additionally, there is a lack of vaccines against bovine hemoplasmosis. In this work, we performed a genomic characterization of hemoplasmas, including two Mexican strains reported in bovines in the last few years. The generated information is a new scenario about the phylogeny of hemoplasmas. Also, we show genomic features among hemoplasmas that strengthen their characteristic genome plasticity of intracellular lifestyles. Finally, the elucidation of antigenic proteins in Mexican strains represents an opportunity to develop molecular detection methods and diagnoses.
“牛支原体”是一种细菌，被描述为在全球范围内感染牛的重要血支原体。目前，已知三种牛血支原体基因组。这项工作旨在描述血支原体的主要基因组特征及其进化关系，并提供通过免疫信息学预测的作为牛血原虫病诊断候选抗原表位的列表。迄今为止，尚无预防这种对全球牛生产造成经济影响的疾病的疫苗。此外，也缺乏针对牛血原虫病的疫苗。在这项工作中，我们对血支原体进行了基因组特征分析，包括过去几年在牛中报道的两株墨西哥菌株。所产生的信息为血支原体的系统发育提供了新的情况。此外，我们展示了血支原体之间的基因组特征，这些特征强化了它们细胞内生活方式所特有的基因组可塑性。最后，阐明墨西哥菌株中的抗原蛋白为开发分子检测方法和诊断提供了契机。
