Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Computer Science, Faculty of Mathematical Sciences, University of Tabriz, Tabriz, Iran.
Drug Discov Today. 2020 Jun;25(6):1034-1042. doi: 10.1016/j.drudis.2020.03.006. Epub 2020 Mar 20.
Computational epitope-based vaccine design is the cornerstone of vaccine development. Owing to the selection of proper compositions [antigens (Ags), epitopes, peptide linkers, and intramolecular adjuvants], epitope-based vaccines are considered a cost- and time-effective approach resulting in the development of vaccines with maximal therapeutic efficacy and minimal adverse reactions. In this review, we provide insights into in silico epitope-based vaccine design and highlight vaccinology procedures used for the development of the next-generation vaccines with high effectiveness.
基于计算表位的疫苗设计是疫苗开发的基石。由于选择了适当的成分[抗原（Ags）、表位、肽接头和分子内佐剂]，基于表位的疫苗被认为是一种具有成本效益和时间效益的方法，可开发出具有最大治疗效果和最小不良反应的疫苗。在这篇综述中，我们深入探讨了基于计算表位的疫苗设计，并强调了用于开发高效下一代疫苗的疫苗学程序。
